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- W4249688348 abstract "Abstract Objective: To investigate the risks of patients with stage IA1-IIA1 cervical cancer after laparoscopic hysterectomy, and whether adjuvant radiotherapy is necessary. Patients and Methods: From January 2013 to December 2016, we retrospectively analyzed 221 patients with cervical cancer of stage IA1-IIA1. Sixty-two patients were treated with laparoscopic hysterectomy and adjuvant radiotherapy (group A), 115 patients only underwent open surgery (group B) and 44 patients received laparoscopic hysterectomy alone (group C). Local recurrence-free survival（LRFS) was the primary outcome, distant metastasis free survival (DMFS) and overall survival (OS) rates were secondary outcomes in the study. Results: The median follow-up time was 58.33 months (range, 56.91-59.76 months) for all the patients. Three groups were balanced in terms of baseline characteristics. The 3-year LRFS rates were 98.4% in group A, 97.4% in group B, and 86.4% in group C, respectively. The LRFS rates of group A and B surpassed group C ( group A vs. B, p=0.634; group A vs. C, p=0.011; group B vs. C, p=0.006). In subgroup analysis of stage IB1-IB3 disease, the 3-year LRFS was 100% in group A , 98.8 % in group B and 83.1% in group C, the 3-year OS rates were 100% in group A, 98.9% in group B, 91.5% in group C. The 3-year LRFS and OS rates on group A and B were significantly superior to group C ( p<0.05 ). No benefits of adjuvant radiotherapy were observed in patients with stage IA and IIA1 cervical cancer. Conclusions: There is a risk of local failure in laparoscopic hysterectomy for early stage cervical cancer. Adjuvant radiotherapy can reduce the risk of recurrence and improve local control for women with early cervical cancer and bring survival benefits for patients with stage IB disease after minimally invasive hysterectomy." @default.
- W4249688348 created "2022-05-12" @default.
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- W4249688348 date "2020-10-05" @default.
- W4249688348 modified "2023-09-22" @default.
- W4249688348 title "What Do Risks Exist After Minimally Invasive Surgery in Patients With Stage IA1-IIA1 Cervical Cancer" @default.
- W4249688348 doi "https://doi.org/10.21203/rs.3.rs-74268/v1" @default.
- W4249688348 hasPublicationYear "2020" @default.
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