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- W4249704363 abstract "Kleinere Proteinmengen genügen mit paramagnetischem Cobalt(II) statt diamagnetischem Zink(II) in der Matrix der Metalloproteinase MMP-12 für die Suche nach schwachen bindenden Wechselwirkungen zwischen Liganden und dem aktiven Zentrum eines Metalloproteins. Die 1H-NMR-Spektroskopie liefert dann qualitative Informationen zur Orientierung des Liganden in dem katalytischen Zentrum, das das Ziel von Wirkstoffen ist (siehe Bild)." @default.
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- W4249704363 date "2004-04-16" @default.
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- W4249704363 title "Paramagnetic Metal Ions in Ligand Screening: The CoII Matrix Metalloproteinase 12" @default.
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- W4249704363 doi "https://doi.org/10.1002/ange.200353453" @default.
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