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- W4249743163 abstract "Flexibilities for sample size allocation are often demanded for achieving multiple study objectives in combination drug trials. The global tests of Hung, Chi and Lipicky are extended for analysis of unbalanced factorial design trials to test the hypothesis that at least one of the non-zero dose combinations of two drugs is more effective than the respective component doses. When the dose combinations have heterogeneous effect sizes, an unbalanced design may induce greater power than the balanced design. An adjusted p-value approach is proposed for testing the individual dose combinations under the condition that the maximum type I error probability is protected. Copyright © 2000 John Wiley & Sons, Ltd." @default.
- W4249743163 created "2022-05-12" @default.
- W4249743163 creator A5083468184 @default.
- W4249743163 date "2000-08-30" @default.
- W4249743163 modified "2023-09-25" @default.
- W4249743163 title "Evaluation of a combination drug with multiple doses in unbalanced factorial design clinical trials" @default.
- W4249743163 doi "https://doi.org/10.1002/1097-0258(20000830)19:16<2079::aid-sim535>3.3.co;2-9" @default.
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