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- W4249743246 abstract "Abstract Objective: Fluorescence Optical Imaging (FOI) demonstrates enhanced microcirculation in finger joints as a sign of inflammation. We wanted to assess the validity and diagnostic performance of FOI measuring synovitis in persons with hand OA, comparing it with magnetic resonance imaging (MRI)- and ultrasound-detected synovitis.Methods: 221 participants with hand OA underwent FOI, contrast-enhanced MRI and ultrasound (grey scale synovitis and power-Doppler activity) examinations of the hands. Fifteen joints in each hand were scored on semi-quantitative scales (grade 0-3) for all modalities. Four FOI images were evaluated: one composite image (Prima Vista Mode; PVM) and three images representing phases of fluorescent dye distribution. Spearman’s correlation coefficients were calculated between sum scores of FOI, MRI and ultrasound. Sensitivity, specificity and area under the curve (AUC) was calculated for FOI using MRI or ultrasound as reference.Results: FOI did not demonstrate enhancement in the first carpometacarpal joint, which was excluded from further analyses. FOI sum scores showed poor to fair correlations with MRI (rho 0.01-0.24) and GS synovitis sum scores (rho 0.12-0.25). None of the FOI images demonstrated both good sensitivity and specificity, and the AUC ranged from 0.50-0.61 and 0.51-0.63 with MRI and GS synovitis as reference, respectively. FOI demonstrated similar diagnostic performance with PD activity and GS synovitis as reference.Conclusion: To conclude, FOI enhancement correlated poorly with synovitis assessed by more established imaging modalities, questioning the value of FOI for the evaluation of synovitis in hand OA." @default.
- W4249743246 created "2022-05-12" @default.
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- W4249743246 date "2020-02-28" @default.
- W4249743246 modified "2023-10-16" @default.
- W4249743246 title "Validity and diagnostic performance of Fluorescence Optical Imaging measuring synovitis in hand osteoarthritis. Baseline results from the Nor-Hand cohort." @default.
- W4249743246 doi "https://doi.org/10.21203/rs.2.24840/v1" @default.
- W4249743246 hasPublicationYear "2020" @default.
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