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- W4249768360 abstract "Use of cyclic double-stranded oligonucleotides containing the binding site for a transcription factor for inhibiting gene expression are disclosed. The inventors propose use of double-stranded oligonucleotides to block DNA attachment of specific transcription factors thereby preventing expression of genes dependent on this transcription factor interaction. Oligonucleotides to HNF-1 transcription factor are used and it is demonstrated that such treatment leads to a block of expression of several liver specific genes under in vitro conditions. The closed oligonucleotides may be used to down-regulate the expression of genes such as fibrinogen and thus may be used for the treatment of coronary heart disease." @default.
- W4249768360 created "2022-05-12" @default.
- W4249768360 date "1994-08-01" @default.
- W4249768360 modified "2023-09-26" @default.
- W4249768360 title "Use of cyclic double-stranded oligonucleotides to inhibit gene expression" @default.
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- W4249768360 doi "https://doi.org/10.1517/13543776.4.8.971" @default.
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