Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249779511> ?p ?o ?g. }
- W4249779511 abstract "Contrasting to rare monogenic forms of hypertension, essential hypertension is the most clinically diagnosed ailment leading to high morbidity and mortality; however, its underlying mechanisms continue to be undeciphered. To assist this endeavor, investigations utilizing rodent models have revealed multiplex genetic architecture for quantitative trait loci (QTLs), for blood pressure (BP), elaborate QTL–QTL interactions and efficacious genome regulations of QTL functions. Although BP is a quantitatively measured trait manifesting in a continuous variation, each QTL governing it appears to behave as an independent and ‘monogenic’ Mendelian determinant. Some QTLs are functionally modularized by epistasis that implies a common pathway or cascade; whereas others belong to parallel epistatic modules. These insights suggest that similar genetic mechanisms probably shepherd the genetic architecture for essential hypertension. Translation of gene discovery to therapeutic targets and diagnostic tools will require a consolidation of functional validation of genes in animal models with association studies in targeted human populations. Key Concepts The quantitative governance of blood pressure variations is realized by several genes or quantitative trait loci (QTLs). Each QTL can operate autonomously and comports in a ‘monogenic’ pattern. Those QTLs that occur to mutually conceal their BP effects can be epistatically modularized, consequently, solving the conundrum of overabundant QTLs in the genome. Despite the puissance of QTLs, potent genome regulations can disallow QTLs to influence blood pressure (BP). In both human and animal association/linkage studies, population-dependence and the influence of genome heterogeneity on exhibiting the amplitude of BP effect are frequently observed occurrences." @default.
- W4249779511 created "2022-05-12" @default.
- W4249779511 creator A5086370706 @default.
- W4249779511 date "2008-09-15" @default.
- W4249779511 modified "2023-09-30" @default.
- W4249779511 title "Molecular Genetics of Polygenic Hypertension" @default.
- W4249779511 cites W1965987217 @default.
- W4249779511 cites W1967497562 @default.
- W4249779511 cites W1968770618 @default.
- W4249779511 cites W1972302507 @default.
- W4249779511 cites W1976741643 @default.
- W4249779511 cites W1981387915 @default.
- W4249779511 cites W1982251587 @default.
- W4249779511 cites W1987895874 @default.
- W4249779511 cites W2003872525 @default.
- W4249779511 cites W2025420466 @default.
- W4249779511 cites W2036707596 @default.
- W4249779511 cites W2051658709 @default.
- W4249779511 cites W2056064218 @default.
- W4249779511 cites W2056590565 @default.
- W4249779511 cites W2057097306 @default.
- W4249779511 cites W2057745256 @default.
- W4249779511 cites W2057826553 @default.
- W4249779511 cites W2082027338 @default.
- W4249779511 cites W2086016312 @default.
- W4249779511 cites W2094970674 @default.
- W4249779511 cites W2106962907 @default.
- W4249779511 cites W2107177169 @default.
- W4249779511 cites W2113023191 @default.
- W4249779511 cites W2116717490 @default.
- W4249779511 cites W2122254253 @default.
- W4249779511 cites W2125941777 @default.
- W4249779511 cites W2126367887 @default.
- W4249779511 cites W2137082124 @default.
- W4249779511 cites W2137978158 @default.
- W4249779511 cites W2138120558 @default.
- W4249779511 cites W2148236819 @default.
- W4249779511 cites W2149808071 @default.
- W4249779511 cites W2149945426 @default.
- W4249779511 cites W2151229583 @default.
- W4249779511 cites W2160294128 @default.
- W4249779511 cites W2164801396 @default.
- W4249779511 cites W2184870906 @default.
- W4249779511 cites W2217809488 @default.
- W4249779511 cites W4235147021 @default.
- W4249779511 cites W4361868871 @default.
- W4249779511 cites W2126771936 @default.
- W4249779511 doi "https://doi.org/10.1002/9780470015902.a0021466" @default.
- W4249779511 hasPublicationYear "2008" @default.
- W4249779511 type Work @default.
- W4249779511 citedByCount "0" @default.
- W4249779511 crossrefType "reference-entry" @default.
- W4249779511 hasAuthorship W4249779511A5086370706 @default.
- W4249779511 hasConcept C104317684 @default.
- W4249779511 hasConcept C106208931 @default.
- W4249779511 hasConcept C106934330 @default.
- W4249779511 hasConcept C122735190 @default.
- W4249779511 hasConcept C135763542 @default.
- W4249779511 hasConcept C141231307 @default.
- W4249779511 hasConcept C142870003 @default.
- W4249779511 hasConcept C153209595 @default.
- W4249779511 hasConcept C175783326 @default.
- W4249779511 hasConcept C186413461 @default.
- W4249779511 hasConcept C199360897 @default.
- W4249779511 hasConcept C21249469 @default.
- W4249779511 hasConcept C2781188995 @default.
- W4249779511 hasConcept C2908647359 @default.
- W4249779511 hasConcept C30481170 @default.
- W4249779511 hasConcept C41008148 @default.
- W4249779511 hasConcept C54355233 @default.
- W4249779511 hasConcept C61727976 @default.
- W4249779511 hasConcept C69991583 @default.
- W4249779511 hasConcept C70721500 @default.
- W4249779511 hasConcept C71924100 @default.
- W4249779511 hasConcept C81941488 @default.
- W4249779511 hasConcept C86803240 @default.
- W4249779511 hasConcept C9287583 @default.
- W4249779511 hasConcept C99454951 @default.
- W4249779511 hasConceptScore W4249779511C104317684 @default.
- W4249779511 hasConceptScore W4249779511C106208931 @default.
- W4249779511 hasConceptScore W4249779511C106934330 @default.
- W4249779511 hasConceptScore W4249779511C122735190 @default.
- W4249779511 hasConceptScore W4249779511C135763542 @default.
- W4249779511 hasConceptScore W4249779511C141231307 @default.
- W4249779511 hasConceptScore W4249779511C142870003 @default.
- W4249779511 hasConceptScore W4249779511C153209595 @default.
- W4249779511 hasConceptScore W4249779511C175783326 @default.
- W4249779511 hasConceptScore W4249779511C186413461 @default.
- W4249779511 hasConceptScore W4249779511C199360897 @default.
- W4249779511 hasConceptScore W4249779511C21249469 @default.
- W4249779511 hasConceptScore W4249779511C2781188995 @default.
- W4249779511 hasConceptScore W4249779511C2908647359 @default.
- W4249779511 hasConceptScore W4249779511C30481170 @default.
- W4249779511 hasConceptScore W4249779511C41008148 @default.
- W4249779511 hasConceptScore W4249779511C54355233 @default.
- W4249779511 hasConceptScore W4249779511C61727976 @default.
- W4249779511 hasConceptScore W4249779511C69991583 @default.
- W4249779511 hasConceptScore W4249779511C70721500 @default.
- W4249779511 hasConceptScore W4249779511C71924100 @default.
- W4249779511 hasConceptScore W4249779511C81941488 @default.