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- W4249865362 abstract "A novel and catalyst-free multicomponent reaction with cyclic tertiary amines, electron-deficient aryl halides or heteroaromatic halides, and Na2S enabled by facile C−N bond cleavage of the cyclic tertiary amines was developed. This direct and operationally simple method can be applied with a wide range of functional groups and provides an efficient and rapid approach to potentially drug-like products containing amine, azaarene, thioether, or phenol ether functionalities in good to excellent yields. The utility of this method was demonstrated by the rapid synthesis of the analgesic ruzadolane." @default.
- W4249865362 created "2022-05-12" @default.
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- W4249865362 date "2017-04-07" @default.
- W4249865362 modified "2023-10-18" @default.
- W4249865362 title "Multicomponent Reactions with Cyclic Tertiary Amines Enabled by Facile C−N Bond Cleavage" @default.
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- W4249865362 doi "https://doi.org/10.1002/ange.201612017" @default.
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