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- W4249879462 abstract "<ns4:p>The centromeric protein CENP-C is a base component of the kinetochore. This protein, along with CENP-A has been shown to adaptively evolve in a number of animal and plant species. In order to determine if CENP-C also evolves in fish species, I attempted to retrieve fish CENP-C sequences from GenBank. No Teleostei CENP-C sequences were found either by name or by BLASTP searches with the vertebrate CENP-C motif sequence. A number of putative Teleostei protein sequences were identified in GenBank that have homology to the C-terminal cupin domain of vertebrate CENP-C. These proteins only have partial homology to the CENP-C motif, but evidence is presented that makes it likely that these fish proteins are orthologs of CENP-C. Interestingly, it was also discovered that the CENP-C motif sequence is also mostly present in M18BP1 proteins of fish and some other vertebrates but not in mammals. This finding may have implications for CENP-C and M18BP1 assembly in centromeric regions of different vertebrate taxa.</ns4:p>" @default.
- W4249879462 created "2022-05-12" @default.
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- W4249879462 date "2015-08-05" @default.
- W4249879462 modified "2023-10-13" @default.
- W4249879462 title "Possible identification of CENP-C in fish and the presence of the CENP-C motif in M18BP1 of vertebrates." @default.
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- W4249879462 doi "https://doi.org/10.12688/f1000research.6823.1" @default.
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