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- W4249894932 abstract "By fura-2 fluorometry, we investigated the direct effects of Ca2+antagonists including a new benzothiazepine, clcntiazem, on the high-K+-evoked increase in the concentration of cytosolic free Ca2+([Ca2+]i) in rat cerebral synaptosomes and cultured hippocampal neurons. In both preparations, metal ions inhibited the high-K+-induced increase in [Ca2+]i, in the following order: La3+> Cd2+≫ Ni2+. Although flunarizine and nicardipine inhibited the K+-induced increase in [Ca2+]i in synaptosomes, other Ca2+antagonists, including clentiazem and nitrendipine, had little effect at 10 μΜ. In hippocampal neurons, clentiazem inhibited the K+-induced increase in [Ca2 +]i at 10 μΜ, as did flunarizine and nicardipine. However, nifedipine and nitrendipine had little effect in either cultured neurons or in synaptosomes." @default.
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- W4249894932 date "1992-01-01" @default.
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- W4249894932 title "Effect of Ca2+Antagonists on High-K+Evoked Increase in [Ca2+]i in Rat Cerebral Synaptosomes and Hippocampal Neurons" @default.
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- W4249894932 doi "https://doi.org/10.1016/s0021-5198(19)39721-5" @default.
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