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- W4249898102 abstract "Visual contrast sensitivity has been shown to be impaired in patients with prodromal and clinical Alzheimer's disease (AD). The utility of this technique as a biomarker is predicated on the ability of the measure to reflect AD-related pathology, both in clinical and preclinical stages. Thus, the goal of this study was to evaluate the relationship between contrast sensitivity and amyloid and tau deposition. 30 participants from the Indiana Alzheimer Disease Center (IADC), including 25 cognitively normal older adults (CN), 4 patients with mild cognitive impairment (MCI), and 1 AD patient underwent frequency doubling technology (FDT-2) to assess contrast sensitivity and [18F]Florbetapir PET scans. Both duration of the iterative FDT exam and mean contrast sensitivity were evaluated. Eighteen of the participants also underwent [18F]Flortaucipir PET scans. PET scans were processed using standard techniques and intensity-normalized to the whole cerebellum ([18F]Florabetapir) or cerebellar crus ([18F]Flortaucipir). The associations between contrast sensitivity and both [18]Florbetapir standardized uptake values with a reference region (SUVR) and [18F]Flortaucipir SUVR were evaluated at a voxel-wise level, covaried for age, sex, and diagnosis when appropriate, and displayed at a threshold of p<0.001 (uncorrected) and minimum cluster size (k)=100 voxels. Mean SUVR from target regions of interest was also extracted, and associations between the regional amyloid and tau measures and contrast sensitivity were assessed using a linear regression model. Significant associations between contrast sensitivity and both amyloid (Figure 1A) and tau (Figure 1B) deposition were observed. The associations remained significant when diagnosis was included as a covariate. When the evaluation was restricted to CNs, significant clusters remained for the association with tau, and at a trend-level for amyloid. Regional associations showed similar patterns of association (Figure 1C and 1D, p<0.01)." @default.
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- W4249898102 date "2017-07-01" @default.
- W4249898102 modified "2023-09-27" @default.
- W4249898102 title "[P1-286]: VISUAL CONTRAST SENSITIVITY IS ASSOCIATED WITH AMYLOID AND TAU DEPOSITION" @default.
- W4249898102 doi "https://doi.org/10.1016/j.jalz.2017.06.302" @default.
- W4249898102 hasPublicationYear "2017" @default.
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