Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249948996> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4249948996 endingPage "578" @default.
- W4249948996 startingPage "565" @default.
- W4249948996 abstract "Semaphorins provide signals that guide growing axons to their appropriate destinations. The secreted semaphorin, Sema3A, mediates repulsive effects on axons from various neuronal populations in embryonic rats. The authors localized Sema3A mRNA expression in the primary olfactory pathway during development, in adult rats, and in adult rats that were subjected to a unilateral olfactory bulbectomy. Developing rats at ages from embryonic day 14 (E14) to E19 expressed Sema3A in the olfactory receptor neurons (ORNs) of the olfactory epithelium and in chondrogenic structures surrounding the nasal cavity. In vitro, ORN axons at E14 avoided substrate-bound Sema3A. Low levels of Sema3A expression persisted in the normal adult epithelium both in ORNs scattered throughout the epithelium and in small clusters. Three days after a unilateral olfactory bulbectomy, Sema3A transcript levels increased in regenerating neurons. High levels of Sema3A transcript were found at 1 week postbulbectomy, persisted for 2 weeks, and diminished by 3 weeks. Several other murine semaphorins (Sema4A, Sema4B, and Sema4C) were expressed differentially in the primary olfactory pathway both during development and regeneration. These findings suggest that Sema3A and perhaps other semaphorins play a role in directing ORNs out of the epithelium and to the olfactory bulb, their target structure, during both development and regeneration. J. Comp. Neurol. 423:565–578, 2000. © 2000 Wiley-Liss, Inc." @default.
- W4249948996 created "2022-05-12" @default.
- W4249948996 creator A5011022093 @default.
- W4249948996 creator A5029501084 @default.
- W4249948996 creator A5039084536 @default.
- W4249948996 creator A5040295133 @default.
- W4249948996 creator A5055708034 @default.
- W4249948996 creator A5066952714 @default.
- W4249948996 creator A5079861863 @default.
- W4249948996 creator A5091834202 @default.
- W4249948996 date "2000-08-07" @default.
- W4249948996 modified "2023-09-27" @default.
- W4249948996 title "Expression of semaphorins in developing and regenerating olfactory epithelium" @default.
- W4249948996 doi "https://doi.org/10.1002/1096-9861(20000807)423:4<565::aid-cne3>3.3.co;2-6" @default.
- W4249948996 hasPublicationYear "2000" @default.
- W4249948996 type Work @default.
- W4249948996 citedByCount "0" @default.
- W4249948996 crossrefType "journal-article" @default.
- W4249948996 hasAuthorship W4249948996A5011022093 @default.
- W4249948996 hasAuthorship W4249948996A5029501084 @default.
- W4249948996 hasAuthorship W4249948996A5039084536 @default.
- W4249948996 hasAuthorship W4249948996A5040295133 @default.
- W4249948996 hasAuthorship W4249948996A5055708034 @default.
- W4249948996 hasAuthorship W4249948996A5066952714 @default.
- W4249948996 hasAuthorship W4249948996A5079861863 @default.
- W4249948996 hasAuthorship W4249948996A5091834202 @default.
- W4249948996 hasConcept C105702510 @default.
- W4249948996 hasConcept C132538176 @default.
- W4249948996 hasConcept C169760540 @default.
- W4249948996 hasConcept C170493617 @default.
- W4249948996 hasConcept C201792869 @default.
- W4249948996 hasConcept C2776805952 @default.
- W4249948996 hasConcept C2776886281 @default.
- W4249948996 hasConcept C2779980732 @default.
- W4249948996 hasConcept C2780187430 @default.
- W4249948996 hasConcept C2780496858 @default.
- W4249948996 hasConcept C529278444 @default.
- W4249948996 hasConcept C55493867 @default.
- W4249948996 hasConcept C86803240 @default.
- W4249948996 hasConcept C95444343 @default.
- W4249948996 hasConceptScore W4249948996C105702510 @default.
- W4249948996 hasConceptScore W4249948996C132538176 @default.
- W4249948996 hasConceptScore W4249948996C169760540 @default.
- W4249948996 hasConceptScore W4249948996C170493617 @default.
- W4249948996 hasConceptScore W4249948996C201792869 @default.
- W4249948996 hasConceptScore W4249948996C2776805952 @default.
- W4249948996 hasConceptScore W4249948996C2776886281 @default.
- W4249948996 hasConceptScore W4249948996C2779980732 @default.
- W4249948996 hasConceptScore W4249948996C2780187430 @default.
- W4249948996 hasConceptScore W4249948996C2780496858 @default.
- W4249948996 hasConceptScore W4249948996C529278444 @default.
- W4249948996 hasConceptScore W4249948996C55493867 @default.
- W4249948996 hasConceptScore W4249948996C86803240 @default.
- W4249948996 hasConceptScore W4249948996C95444343 @default.
- W4249948996 hasIssue "4" @default.
- W4249948996 hasLocation W42499489961 @default.
- W4249948996 hasOpenAccess W4249948996 @default.
- W4249948996 hasPrimaryLocation W42499489961 @default.
- W4249948996 hasRelatedWork W1539815787 @default.
- W4249948996 hasRelatedWork W1971937309 @default.
- W4249948996 hasRelatedWork W2002194300 @default.
- W4249948996 hasRelatedWork W2014260701 @default.
- W4249948996 hasRelatedWork W2032356857 @default.
- W4249948996 hasRelatedWork W2065142466 @default.
- W4249948996 hasRelatedWork W2080472416 @default.
- W4249948996 hasRelatedWork W2094953798 @default.
- W4249948996 hasRelatedWork W2102398138 @default.
- W4249948996 hasRelatedWork W2371575472 @default.
- W4249948996 hasVolume "423" @default.
- W4249948996 isParatext "false" @default.
- W4249948996 isRetracted "false" @default.
- W4249948996 workType "article" @default.