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- W4249951710 abstract "Complex disorders like Gulf War illness (GWI) often defy diagnosis on the basis of a single biomarker and may only be distinguishable by considering the co-expression of multiple markers measured in response to a challenge. We demonstrate the practical application of such an approach using an example where blood was collected from 26 GWI, 13 healthy control subjects, and 9 unhealthy controls with chronic fatigue at three points during a graded exercise challenge. A 3-way multivariate projection model based on 12 markers of endocrine and immune function was constructed using a training set of n = 10 GWI and n = 11 healthy controls. These groups were separated almost completely on the basis of two co-expression patterns. In a separate test set these same features allowed for discrimination of new GWI subjects (n = 16) from unhealthy (n = 9) and healthy control subjects with a sensitivity of 70% and a specificity of 90%." @default.
- W4249951710 created "2022-05-12" @default.
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- W4249951710 date "2018-01-01" @default.
- W4249951710 modified "2023-09-25" @default.
- W4249951710 title "Exploring the Diagnostic Potential of Immune Biomarker Co-expression in Gulf War Illness" @default.
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- W4249951710 doi "https://doi.org/10.1007/978-1-4939-7828-1_7" @default.
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