Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249969597> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4249969597 endingPage "361" @default.
- W4249969597 startingPage "356" @default.
- W4249969597 abstract "The influence of T lymphocyte (T cell) subsets on the proliferation of the blood neutrophilic, macrophagic, and eosinophilic cluster and colony (aggregate) forming cells (CFC) was evaluated. The T cells and the CFC-enriched B-null cells (mononuclear cells depleted of monocytes and T cells) and null cells (B-null) cells depleted of B lymphocytes) were separated from the blood of normal individuals. The population enriched for OKT4 (T4 cells) monoclonal antibody-binding T helper/inducer cells and for OKT8 (T8 cells) monoclonal antibody- binding T suppressor/cytotoxic cells were separated from the T cells or mononuclear cells depleted of monocytes by negative enrichment using an immunoadherence “panning” method. These separated cell populations were cultured separately, and the B-null or null cells were cocultured with the T, T4, and T8 cells in agar medium in the presence and absence of an exogenous source of colony-stimulating activity (CSA). The cultures were evaluated at day 14. The B-null and null cells, but not the T cells or subsets, contained CFC. The number of CFC proliferated from the B-null or null cells increased significantly (p less than 0.001) in cocultures with unseparated T and T8 cells in a dose-dependent manner. The T4 cells neither promoted nor inhibited the CFC growth. The T8 population was a better promoter (p less than 0.01) of CFC growth than the unseparated T cells. This suggests that the CFC promoting effect of the unseparated T cells is probably due to the influence of the T8 subset present within the T cells. The proportion of the neutrophilic, macrophagic, and eosinophilic CFC that proliferated in these cultures was comparable under the influence of the T and T8 cells. The results of these studies indicate that the T8 population, which is the suppressor in the classical immune system, promotes the growth of the blood CFC. We speculate that the T cells are involved in the regulation of granulopoiesis in vivo." @default.
- W4249969597 created "2022-05-12" @default.
- W4249969597 creator A5008928623 @default.
- W4249969597 creator A5076056560 @default.
- W4249969597 date "1984-02-01" @default.
- W4249969597 modified "2023-10-01" @default.
- W4249969597 title "Regulation of normal human blood neutrophilic, macrophagic, and eosinophilic committed stem cell proliferation by autologous blood T lymphocyte subsets" @default.
- W4249969597 doi "https://doi.org/10.1182/blood.v63.2.356.bloodjournal632356" @default.
- W4249969597 hasPublicationYear "1984" @default.
- W4249969597 type Work @default.
- W4249969597 citedByCount "1" @default.
- W4249969597 crossrefType "journal-article" @default.
- W4249969597 hasAuthorship W4249969597A5008928623 @default.
- W4249969597 hasAuthorship W4249969597A5076056560 @default.
- W4249969597 hasBestOaLocation W42499695971 @default.
- W4249969597 hasConcept C121853132 @default.
- W4249969597 hasConcept C129374314 @default.
- W4249969597 hasConcept C131665280 @default.
- W4249969597 hasConcept C137061746 @default.
- W4249969597 hasConcept C153911025 @default.
- W4249969597 hasConcept C154317977 @default.
- W4249969597 hasConcept C202751555 @default.
- W4249969597 hasConcept C203014093 @default.
- W4249969597 hasConcept C2776090121 @default.
- W4249969597 hasConcept C2908647359 @default.
- W4249969597 hasConcept C39347974 @default.
- W4249969597 hasConcept C54355233 @default.
- W4249969597 hasConcept C55493867 @default.
- W4249969597 hasConcept C71924100 @default.
- W4249969597 hasConcept C81885089 @default.
- W4249969597 hasConcept C86803240 @default.
- W4249969597 hasConcept C8891405 @default.
- W4249969597 hasConcept C99454951 @default.
- W4249969597 hasConceptScore W4249969597C121853132 @default.
- W4249969597 hasConceptScore W4249969597C129374314 @default.
- W4249969597 hasConceptScore W4249969597C131665280 @default.
- W4249969597 hasConceptScore W4249969597C137061746 @default.
- W4249969597 hasConceptScore W4249969597C153911025 @default.
- W4249969597 hasConceptScore W4249969597C154317977 @default.
- W4249969597 hasConceptScore W4249969597C202751555 @default.
- W4249969597 hasConceptScore W4249969597C203014093 @default.
- W4249969597 hasConceptScore W4249969597C2776090121 @default.
- W4249969597 hasConceptScore W4249969597C2908647359 @default.
- W4249969597 hasConceptScore W4249969597C39347974 @default.
- W4249969597 hasConceptScore W4249969597C54355233 @default.
- W4249969597 hasConceptScore W4249969597C55493867 @default.
- W4249969597 hasConceptScore W4249969597C71924100 @default.
- W4249969597 hasConceptScore W4249969597C81885089 @default.
- W4249969597 hasConceptScore W4249969597C86803240 @default.
- W4249969597 hasConceptScore W4249969597C8891405 @default.
- W4249969597 hasConceptScore W4249969597C99454951 @default.
- W4249969597 hasIssue "2" @default.
- W4249969597 hasLocation W42499695971 @default.
- W4249969597 hasOpenAccess W4249969597 @default.
- W4249969597 hasPrimaryLocation W42499695971 @default.
- W4249969597 hasRelatedWork W10572828 @default.
- W4249969597 hasRelatedWork W11827480 @default.
- W4249969597 hasRelatedWork W19015525 @default.
- W4249969597 hasRelatedWork W22714539 @default.
- W4249969597 hasRelatedWork W35838909 @default.
- W4249969597 hasRelatedWork W3805321 @default.
- W4249969597 hasRelatedWork W45375794 @default.
- W4249969597 hasRelatedWork W50953351 @default.
- W4249969597 hasRelatedWork W51068662 @default.
- W4249969597 hasRelatedWork W5261971 @default.
- W4249969597 hasVolume "63" @default.
- W4249969597 isParatext "false" @default.
- W4249969597 isRetracted "false" @default.
- W4249969597 workType "article" @default.