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- W4250028038 abstract "Like a spy master who convinces an evil agent to work for the good guys, Alison Narayan wants to turn the enzymes used by cyanobacteria to produce a life-threatening paralysis poison—saxitoxin—into machines that build lifesaving drugs. The enzymes that make saxitoxin have exquisite chemistry skills, including the enviable ability to install oxygen groups in hard-to-reach places on complex carbon molecules. That task is particularly hard for synthetic chemists but is also really important for drug development—those oxygen groups can modify a molecule’s biological activity. Narayan isn’t the first chemist to try to make enzymes do her bidding. Protein engineers spend months, even years, rejiggering a protein to perform a single task on a single substrate. But Narayan’s plan is to coax enzymes into doing sophisticated chemistry on a wide variety of substrates. To accomplish that, she wants to mine microbial genomes for enzymes with interesting chemistry skills, engineer the enzymes" @default.
- W4250028038 created "2022-05-12" @default.
- W4250028038 creator A5028477793 @default.
- W4250028038 date "2016-08-22" @default.
- W4250028038 modified "2023-09-27" @default.
- W4250028038 title "Alison Narayan: Enzyme Mastermind" @default.
- W4250028038 doi "https://doi.org/10.1021/cen-09433-cover12" @default.
- W4250028038 hasPublicationYear "2016" @default.
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