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- W4250049741 abstract "Immunomodulators cause changes in neopterin- release from purified macrophages or peripheral blood mononuclear cells by affecting the macrophage and T cell subsets activity, the intracellular cGMP/cAMP balance, or the intracellular pteridines-related biochemical pathways. Increased neopterin release was achieved by γ-IFN or its inducers (PHA, IL-2), by interfering with the biopterin production by increased levels of cGMP or by decreasing the activity of the T suppressor cells. The released neopterin levels decreased due to decreased macrophage and T-helper cell activity or due to increased levels of cAMP. The in vitro effect of the immunomodulators has to be taken into account when assessing the neopterin levels in immunomodulators-treated patients." @default.
- W4250049741 created "2022-05-12" @default.
- W4250049741 date "1988-05-01" @default.
- W4250049741 modified "2023-09-30" @default.
- W4250049741 title "75 years of the AAI" @default.
- W4250049741 doi "https://doi.org/10.1016/0167-5699(88)91191-7" @default.
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- W4250049741 hasPublicationYear "1988" @default.
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