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- W4250052595 abstract "Abstract All metal ions, whether essential or nonessential, are toxic when present in excess. Metabolic disorders in which metal ion overload is a key contributing factor include hemochromatosis, β‐thalassemia, Wilson's disease, Menkes syndrome, and Friedreich's ataxia. For some metal ions, overload conditions may come about as a result of excess oral, inhalation, or dermal exposure. In order to correct a metal ion overload condition, an appropriate ligand choice may speed up the elimination or safely sequester the excess metal ion, and may be the treatment of choice. A number of effective chelating agents are discussed, including desferrioxamine, deferiprone, D ‐penicillamine, and copper– histidine chelate. Marginal overload conditions may lead to marginal deficiency of another metal ion, a result, paradoxically, from single metal ion supplementation. An example would be marginal iron overload, resulting from iron supplement use in excess of need, which leads to marginal manganese deficiency. Such effects are due to metal ion interaction effects in vivo ." @default.
- W4250052595 created "2022-05-12" @default.
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- W4250052595 date "2011-12-15" @default.
- W4250052595 modified "2023-09-24" @default.
- W4250052595 title "Medicinal Inorganic Chemistry: Sequestration or Removal in Metal Ion Overload Disorders" @default.
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- W4250052595 doi "https://doi.org/10.1002/9781119951438.eibc0368" @default.
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