Matches in SemOpenAlex for { <https://semopenalex.org/work/W4250058946> ?p ?o ?g. }
- W4250058946 abstract "Background Etoricoxib is a selective cyclo‐oxygenase‐2 (COX‐2) inhibitor licensed for the relief of chronic pain in osteoarthritis and rheumatoid arthritis, and acute pain in some jurisdictions. This class of drugs is believed to be associated with fewer upper gastrointestinal adverse effects than conventional non‐steroidal anti‐inflammatory drugs (NSAIDs). One additional study in acute postoperative pain has been published since the original review was completed in Issue 2, 2009. Objectives To assess the analgesic efficacy and adverse effects of a single oral dose of etoricoxib for moderate to severe postoperative pain. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, the Oxford Pain Database, ClinicalTrials.gov, and reference lists of articles. The date of the most recent search was 3 January 2012. Selection criteria Randomised, double‐blind, placebo‐controlled clinical trials of single dose, oral etoricoxib for acute postoperative pain in adults. Data collection and analysis Two review authors independently considered trials for inclusion in the review, assessed quality, and extracted data. We used the area under the pain relief versus time curve to derive the proportion of participants prescribed etoricoxib or placebo with at least 50% pain relief over six hours, using validated equations. We calculated relative risk (RR) and number needed to treat to benefit (NNT). We used information on use of rescue medication to calculate the proportion of participants requiring rescue medication and the weighted mean of the median time to use. We also collected information on adverse effects. Main results One additional study has been added to this updated review, making a total of six included studies with 1214 participants in comparisons of etoricoxib with placebo. All six studies reported on the 120 mg dose (798 participants in a comparison with placebo). At least 50% pain relief was reported by 66% with etoricoxib 120 mg and 12% with placebo (NNT 1.8 (1.7 to 2.0)). For dental studies only the NNT was 1.6 (1.5 to 1.8). Although the new study almost doubled the number of participants in included studies it added only about 25% more data for the 120 mg dose and the result was unchanged. Other doses (60, 90, 180, and 240 mg) were each studied in only one treatment arm and we did not undertake pooled analysis. Significantly fewer participants used rescue medication over 24 hours when taking etoricoxib 120 mg than placebo (NNT to prevent remedication 2.2 (1.9 to 2.8)), and the median time to use of rescue medication was 20 hours for etoricoxib and two hours for placebo. Adverse events were reported at a similar rate to placebo, with no serious events. Authors' conclusions The additional study did not change the results from the first review published in 2009, but does make the result more robust. Single dose oral etoricoxib produces high levels of good quality pain relief after surgery and adverse events did not differ from placebo. The 120 mg dose is as effective as, or better than, other commonly used analgesics." @default.
- W4250058946 created "2022-05-12" @default.
- W4250058946 creator A5000962827 @default.
- W4250058946 creator A5077191679 @default.
- W4250058946 creator A5083618919 @default.
- W4250058946 date "2012-04-18" @default.
- W4250058946 modified "2023-10-03" @default.
- W4250058946 title "Single dose oral etoricoxib for acute postoperative pain in adults" @default.
- W4250058946 cites W147691740 @default.
- W4250058946 cites W1535268597 @default.
- W4250058946 cites W1650178754 @default.
- W4250058946 cites W1673301128 @default.
- W4250058946 cites W1963822178 @default.
- W4250058946 cites W1964260473 @default.
- W4250058946 cites W1967631826 @default.
- W4250058946 cites W1971058348 @default.
- W4250058946 cites W1986215651 @default.
- W4250058946 cites W1987834296 @default.
- W4250058946 cites W1999315296 @default.
- W4250058946 cites W2000442546 @default.
- W4250058946 cites W2002357240 @default.
- W4250058946 cites W2003491622 @default.
- W4250058946 cites W2003867452 @default.
- W4250058946 cites W2011914532 @default.
- W4250058946 cites W2033223166 @default.
- W4250058946 cites W2037206834 @default.
- W4250058946 cites W2037565846 @default.
- W4250058946 cites W2041356923 @default.
- W4250058946 cites W2045994976 @default.
- W4250058946 cites W2064215587 @default.
- W4250058946 cites W2071681089 @default.
- W4250058946 cites W2072856001 @default.
- W4250058946 cites W2081654187 @default.
- W4250058946 cites W2092233783 @default.
- W4250058946 cites W2092890771 @default.
- W4250058946 cites W2092960055 @default.
- W4250058946 cites W2111149452 @default.
- W4250058946 cites W2116446898 @default.
- W4250058946 cites W2117227343 @default.
- W4250058946 cites W2138777283 @default.
- W4250058946 cites W2146447031 @default.
- W4250058946 cites W2159085507 @default.
- W4250058946 cites W4238081703 @default.
- W4250058946 cites W4252841911 @default.
- W4250058946 cites W2595437246 @default.
- W4250058946 doi "https://doi.org/10.1002/14651858.cd004309.pub3" @default.
- W4250058946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22513922" @default.
- W4250058946 hasPublicationYear "2012" @default.
- W4250058946 type Work @default.
- W4250058946 citedByCount "26" @default.
- W4250058946 countsByYear W42500589462012 @default.
- W4250058946 countsByYear W42500589462013 @default.
- W4250058946 countsByYear W42500589462014 @default.
- W4250058946 countsByYear W42500589462015 @default.
- W4250058946 countsByYear W42500589462017 @default.
- W4250058946 countsByYear W42500589462018 @default.
- W4250058946 countsByYear W42500589462019 @default.
- W4250058946 countsByYear W42500589462020 @default.
- W4250058946 countsByYear W42500589462021 @default.
- W4250058946 countsByYear W42500589462023 @default.
- W4250058946 crossrefType "reference-entry" @default.
- W4250058946 hasAuthorship W4250058946A5000962827 @default.
- W4250058946 hasAuthorship W4250058946A5077191679 @default.
- W4250058946 hasAuthorship W4250058946A5083618919 @default.
- W4250058946 hasConcept C126322002 @default.
- W4250058946 hasConcept C142724271 @default.
- W4250058946 hasConcept C17744445 @default.
- W4250058946 hasConcept C197934379 @default.
- W4250058946 hasConcept C199539241 @default.
- W4250058946 hasConcept C204787440 @default.
- W4250058946 hasConcept C27081682 @default.
- W4250058946 hasConcept C2776164576 @default.
- W4250058946 hasConcept C2776214540 @default.
- W4250058946 hasConcept C2779473830 @default.
- W4250058946 hasConcept C2780820201 @default.
- W4250058946 hasConcept C42219234 @default.
- W4250058946 hasConcept C44249647 @default.
- W4250058946 hasConcept C535046627 @default.
- W4250058946 hasConcept C67774102 @default.
- W4250058946 hasConcept C71924100 @default.
- W4250058946 hasConcept C82789193 @default.
- W4250058946 hasConceptScore W4250058946C126322002 @default.
- W4250058946 hasConceptScore W4250058946C142724271 @default.
- W4250058946 hasConceptScore W4250058946C17744445 @default.
- W4250058946 hasConceptScore W4250058946C197934379 @default.
- W4250058946 hasConceptScore W4250058946C199539241 @default.
- W4250058946 hasConceptScore W4250058946C204787440 @default.
- W4250058946 hasConceptScore W4250058946C27081682 @default.
- W4250058946 hasConceptScore W4250058946C2776164576 @default.
- W4250058946 hasConceptScore W4250058946C2776214540 @default.
- W4250058946 hasConceptScore W4250058946C2779473830 @default.
- W4250058946 hasConceptScore W4250058946C2780820201 @default.
- W4250058946 hasConceptScore W4250058946C42219234 @default.
- W4250058946 hasConceptScore W4250058946C44249647 @default.
- W4250058946 hasConceptScore W4250058946C535046627 @default.
- W4250058946 hasConceptScore W4250058946C67774102 @default.
- W4250058946 hasConceptScore W4250058946C71924100 @default.
- W4250058946 hasConceptScore W4250058946C82789193 @default.
- W4250058946 hasLocation W42500589461 @default.
- W4250058946 hasLocation W42500589462 @default.