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- W4250079069 abstract "Schwann cell proliferation is a prominent feature of the normal response of a peripheral nerve fibre bundle to injury. In this report we have attempted to analyse the consequence of inhibiting this response using the cross-linking alkylating agent mitomycin C. In the presence of the drug, Schwann cell division was inhibited within a region about the site of injection. In this region myelin breakdown was delayed relative to that occurring distally and in control fibres: even after 3 weeks many Schwann cells had failed to phagocytose their myelin. Regeneration subsequently took place—certain morphological features of the repaired mitomycin C-treated zones are discussed. It is concluded that dilution of debris by successive Schwann cell divisions is necessary during the cellular response to injury in a peripheral nerve fibre bundle." @default.
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- W4250079069 date "1977-01-01" @default.
- W4250079069 modified "2023-09-26" @default.
- W4250079069 title "THE EFFECTS OF MITOMYCIN C ON THE PROCESS OF REGENERATION IN THE MAMMALIAN PERIPHERAL NERVOUS SYSTEM" @default.
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- W4250079069 doi "https://doi.org/10.1111/j.1365-2990.1977.tb00570.x" @default.
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