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- W4250080517 abstract "Inflammation and altered microglial activity have been implicated in the pathophysiology of Alzheimer's disease (AD), but there are few observations relating in vivo microglial indices to other AD markers. We report on relationships between a marker of microglial activation ([11 C]PBR28 PET), brain atrophy, and plasma biomarkers. 31 participants, including 7 AD, 7 MCI, 9 older adults with cognitive complaints but no deficits (CC), and 8 healthy controls (CN) received [11 C]PBR28 PET scans [1]. Scans were intensity-normalized by injected dose per body weight; the mean value from whole brain grey and white matter (GM+WM) was extracted. Structural MRI scans from the baseline PET visit (n=31) and at follow-up 1–1.5 years later (n=22) were processed using Freesurfer 5.1 to extract atrophy measurements. 135 quality-controlled analytes from the multi-analyte Myriad Rules Based Medicine (RBM) Discovery Panel were obtained from blood samples collected at the follow-up visit (n=22). The relationships between [11 C]PBR28 measures, follow-up atrophy adjusted for baseline atrophy, and RBM analyte levels were assessed with appropriate statistical controls. Mean [11 C]PBR28 PET signal from the GM+WM was inversely associated with brain atrophy at follow-up. GM+WM PBR28 was related to mean precuneus cortical thickness at follow-up (r = 0.519, p = 0.027; Figure 1A) adjusted for baseline precuneus thickness. [11 C]PBR28 signal was also related to RBM analytes including BDNF (r = -0.496, p = 0.01; Figure 1B), clusterin (r = -0.417, p = 0.03; Figure 1C), and Regulated on Activation Normal T Cell Expressed and Secreted (RANTES) (r = -0.473, p = 0.01; Figure 1D) analyte levels. These findings were independent of diagnosis and APOE genotype." @default.
- W4250080517 created "2022-05-12" @default.
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- W4250080517 date "2013-07-01" @default.
- W4250080517 modified "2023-10-17" @default.
- W4250080517 title "P1-315: Relationship of microglial activation measured by [11C]PBR28 PET, atrophy on MRI and plasma biomarkers in individuals with and at-risk for Alzheimer's disease" @default.
- W4250080517 doi "https://doi.org/10.1016/j.jalz.2013.05.541" @default.
- W4250080517 hasPublicationYear "2013" @default.
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