Matches in SemOpenAlex for { <https://semopenalex.org/work/W4250097921> ?p ?o ?g. }
- W4250097921 endingPage "686" @default.
- W4250097921 startingPage "680" @default.
- W4250097921 abstract "Abstract Previously we reported that ErbB4 played a protective role in chronic liver injury and hepatocellular carcinoma. Herein, we examined the role of ErbB4 in the development of colitis-associated cancer (CAC) in ErbB4 knockout mice models, in vitro cell lines and clinical samples. We found that ErbB4 deficiency may lead to more severe inflammation, slower recovery and the development of CAC. Further, loss of ErbB4 could activate Kras by upregulating rate-limiting enzymes in cholesterol metabolism pathway through interacting with the transcription factor Srebf1. In clinic samples, ErbB4 is downregulated in colonic tissues from patients with Crohn’s disease. And data from The Cancer Genome Atlas also showed significant negative correlation between ErbB4 and several cholesterol metabolic enzymes. In summary, our study uncovers ErbB4 as a protector in the development of CAC, for its loss could activate Kras by upregulating cholesterol metabolism." @default.
- W4250097921 created "2022-05-12" @default.
- W4250097921 creator A5002768111 @default.
- W4250097921 creator A5002883252 @default.
- W4250097921 creator A5007925508 @default.
- W4250097921 creator A5013052217 @default.
- W4250097921 creator A5030203947 @default.
- W4250097921 creator A5040384421 @default.
- W4250097921 creator A5046035325 @default.
- W4250097921 creator A5060681519 @default.
- W4250097921 creator A5082396747 @default.
- W4250097921 creator A5083247827 @default.
- W4250097921 creator A5084906802 @default.
- W4250097921 creator A5085699342 @default.
- W4250097921 date "2018-11-17" @default.
- W4250097921 modified "2023-09-24" @default.
- W4250097921 title "ErbB4 acts as a suppressor in colitis and its associated carcinoma by negatively regulating cholesterol metabolism" @default.
- W4250097921 cites W1809717564 @default.
- W4250097921 cites W1974024530 @default.
- W4250097921 cites W1986685158 @default.
- W4250097921 cites W2006256030 @default.
- W4250097921 cites W2013632290 @default.
- W4250097921 cites W2015336843 @default.
- W4250097921 cites W2034887388 @default.
- W4250097921 cites W2047316934 @default.
- W4250097921 cites W2054496859 @default.
- W4250097921 cites W2057386188 @default.
- W4250097921 cites W2057871099 @default.
- W4250097921 cites W2061678430 @default.
- W4250097921 cites W2097541122 @default.
- W4250097921 cites W2159921182 @default.
- W4250097921 cites W2209591601 @default.
- W4250097921 cites W2228024052 @default.
- W4250097921 cites W2273081561 @default.
- W4250097921 cites W2588483860 @default.
- W4250097921 cites W2590847576 @default.
- W4250097921 cites W2614197161 @default.
- W4250097921 cites W2784611114 @default.
- W4250097921 cites W2803768714 @default.
- W4250097921 cites W4252021281 @default.
- W4250097921 doi "https://doi.org/10.1093/carcin/bgy164" @default.
- W4250097921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30452622" @default.
- W4250097921 hasPublicationYear "2018" @default.
- W4250097921 type Work @default.
- W4250097921 citedByCount "4" @default.
- W4250097921 countsByYear W42500979212021 @default.
- W4250097921 countsByYear W42500979212022 @default.
- W4250097921 countsByYear W42500979212023 @default.
- W4250097921 crossrefType "journal-article" @default.
- W4250097921 hasAuthorship W4250097921A5002768111 @default.
- W4250097921 hasAuthorship W4250097921A5002883252 @default.
- W4250097921 hasAuthorship W4250097921A5007925508 @default.
- W4250097921 hasAuthorship W4250097921A5013052217 @default.
- W4250097921 hasAuthorship W4250097921A5030203947 @default.
- W4250097921 hasAuthorship W4250097921A5040384421 @default.
- W4250097921 hasAuthorship W4250097921A5046035325 @default.
- W4250097921 hasAuthorship W4250097921A5060681519 @default.
- W4250097921 hasAuthorship W4250097921A5082396747 @default.
- W4250097921 hasAuthorship W4250097921A5083247827 @default.
- W4250097921 hasAuthorship W4250097921A5084906802 @default.
- W4250097921 hasAuthorship W4250097921A5085699342 @default.
- W4250097921 hasConcept C101544691 @default.
- W4250097921 hasConcept C121608353 @default.
- W4250097921 hasConcept C126322002 @default.
- W4250097921 hasConcept C134018914 @default.
- W4250097921 hasConcept C170493617 @default.
- W4250097921 hasConcept C2775862500 @default.
- W4250097921 hasConcept C2776914184 @default.
- W4250097921 hasConcept C2778163477 @default.
- W4250097921 hasConcept C2780943970 @default.
- W4250097921 hasConcept C2781187634 @default.
- W4250097921 hasConcept C502942594 @default.
- W4250097921 hasConcept C526805850 @default.
- W4250097921 hasConcept C71924100 @default.
- W4250097921 hasConcept C86803240 @default.
- W4250097921 hasConceptScore W4250097921C101544691 @default.
- W4250097921 hasConceptScore W4250097921C121608353 @default.
- W4250097921 hasConceptScore W4250097921C126322002 @default.
- W4250097921 hasConceptScore W4250097921C134018914 @default.
- W4250097921 hasConceptScore W4250097921C170493617 @default.
- W4250097921 hasConceptScore W4250097921C2775862500 @default.
- W4250097921 hasConceptScore W4250097921C2776914184 @default.
- W4250097921 hasConceptScore W4250097921C2778163477 @default.
- W4250097921 hasConceptScore W4250097921C2780943970 @default.
- W4250097921 hasConceptScore W4250097921C2781187634 @default.
- W4250097921 hasConceptScore W4250097921C502942594 @default.
- W4250097921 hasConceptScore W4250097921C526805850 @default.
- W4250097921 hasConceptScore W4250097921C71924100 @default.
- W4250097921 hasConceptScore W4250097921C86803240 @default.
- W4250097921 hasFunder F4320321001 @default.
- W4250097921 hasFunder F4320336125 @default.
- W4250097921 hasIssue "5" @default.
- W4250097921 hasLocation W42500979211 @default.
- W4250097921 hasLocation W42500979212 @default.
- W4250097921 hasOpenAccess W4250097921 @default.
- W4250097921 hasPrimaryLocation W42500979211 @default.
- W4250097921 hasRelatedWork W1966834268 @default.
- W4250097921 hasRelatedWork W1972175381 @default.