FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4250100903> ?p ?o ?g. }

• W4250100903 endingPage "576" @default.
• W4250100903 startingPage "563" @default.
• W4250100903 abstract "The influences of aging on the response of urinary bladder detrusor smooth muscle in response to neurogenic stimulation (electric field stimulation) were investigated in rats aged 3–4 months (young) and 18–20 months (old). In addition, age-associated changes in calcium homeostasis were evaluated by comparing the basal intracellular free calcium concentration ([Ca2+]i), the change of [Ca2+]i in response to field stimulation, the contractile response at different extracellular calcium concentrations (Ca2+ = 1.8, 0.6, and 0 mM), and the sensitivity to the L-type calcium channel blocker. In both groups, the frequency-response curve in response to field stimulation (1–32 HZ) was similar. The contractile response to field stimulation was biphasic (phasic and tonic). The phasic/tonic ratio at different frequencies was similar between the two groups. The contractile responses were equally inhibited by atropine (1 μM) and preincubation with α,β-methylene ATP (50 μM). Tetrodotoxin (1 μM) virtually abolished the responses to field stimulation in both groups. The biphasic components showed different sensitivities to diltiazem and low calcium. The tonic component was more readily inhibited by diltiazem, whereas the phasic component was more sensitive to low calcium medium. In general, the response to lower frequency stimulations was more sensitive to both diltiazem and low calcium. The aged group was more sensitive to the inhibitory effects of both low calcium and diltiazem. In Ca2+-free medium, the contractile response to higher frequency (e.g., 32 Hz) was temporarily preserved in most of the preparations. This response disappeared after repeated stimulation. The magnitude of this Ca2+-free response to 32 Hz stimulation was significantly lower in the aged group than in the young group (18.1 ± 1.4 vs. 29.1 ± 3.2% of the control response in normal Tyrode medium, P < 0.05). The basal [Ca2+]i levels were similar in the two groups (young: 131 ± 12 nM, n = 5; old: 118 ± 10 nM, n = 4, P > 0.05). The magnitude and time course of the [Ca2+]i response to field stimulation were also similar in the two groups. It is concluded that aging seems to have little effect on the neuromuscular activities of rat urinary bladder. However, the calcium homeostasis may be altered as evidenced by the increased sensitivity to diltiazem and low extracellular calcium. © 1996 Wiley-Liss, Inc." @default.
• W4250100903 created "2022-05-12" @default.
• W4250100903 creator A5042687042 @default.
• W4250100903 creator A5044352948 @default.
• W4250100903 creator A5055176143 @default.
• W4250100903 date "1996-01-01" @default.
• W4250100903 modified "2023-10-01" @default.
• W4250100903 title "Age‐related differential susceptibility to calcium channel blocker and low calcium medium in rat detrusor muscle: Response to field stimulation" @default.
• W4250100903 doi "https://doi.org/10.1002/(sici)1520-6777(1996)15:5<563::aid-nau12>3.3.co;2-z" @default.
• W4250100903 hasPublicationYear "1996" @default.
• W4250100903 type Work @default.
• W4250100903 citedByCount "0" @default.
• W4250100903 crossrefType "journal-article" @default.
• W4250100903 hasAuthorship W4250100903A5042687042 @default.
• W4250100903 hasAuthorship W4250100903A5044352948 @default.
• W4250100903 hasAuthorship W4250100903A5055176143 @default.
• W4250100903 hasConcept C126322002 @default.
• W4250100903 hasConcept C127573956 @default.
• W4250100903 hasConcept C134018914 @default.
• W4250100903 hasConcept C185592680 @default.
• W4250100903 hasConcept C18699975 @default.
• W4250100903 hasConcept C24998067 @default.
• W4250100903 hasConcept C2776050358 @default.
• W4250100903 hasConcept C2776741139 @default.
• W4250100903 hasConcept C2776741303 @default.
• W4250100903 hasConcept C2777022698 @default.
• W4250100903 hasConcept C2780356492 @default.
• W4250100903 hasConcept C30979828 @default.
• W4250100903 hasConcept C519063684 @default.
• W4250100903 hasConcept C71924100 @default.
• W4250100903 hasConceptScore W4250100903C126322002 @default.
• W4250100903 hasConceptScore W4250100903C127573956 @default.
• W4250100903 hasConceptScore W4250100903C134018914 @default.
• W4250100903 hasConceptScore W4250100903C185592680 @default.
• W4250100903 hasConceptScore W4250100903C18699975 @default.
• W4250100903 hasConceptScore W4250100903C24998067 @default.
• W4250100903 hasConceptScore W4250100903C2776050358 @default.
• W4250100903 hasConceptScore W4250100903C2776741139 @default.
• W4250100903 hasConceptScore W4250100903C2776741303 @default.
• W4250100903 hasConceptScore W4250100903C2777022698 @default.
• W4250100903 hasConceptScore W4250100903C2780356492 @default.
• W4250100903 hasConceptScore W4250100903C30979828 @default.
• W4250100903 hasConceptScore W4250100903C519063684 @default.
• W4250100903 hasConceptScore W4250100903C71924100 @default.
• W4250100903 hasIssue "5" @default.
• W4250100903 hasLocation W42501009031 @default.
• W4250100903 hasOpenAccess W4250100903 @default.
• W4250100903 hasPrimaryLocation W42501009031 @default.
• W4250100903 hasRelatedWork W1953513934 @default.
• W4250100903 hasRelatedWork W1966221777 @default.
• W4250100903 hasRelatedWork W2016271841 @default.
• W4250100903 hasRelatedWork W2034698869 @default.
• W4250100903 hasRelatedWork W2039661997 @default.
• W4250100903 hasRelatedWork W2113250804 @default.
• W4250100903 hasRelatedWork W2309136548 @default.
• W4250100903 hasRelatedWork W2345584884 @default.
• W4250100903 hasRelatedWork W2898348549 @default.
• W4250100903 hasRelatedWork W2980826060 @default.
• W4250100903 hasVolume "15" @default.
• W4250100903 isParatext "false" @default.
• W4250100903 isRetracted "false" @default.
• W4250100903 workType "article" @default.