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- W4250136207 abstract "La obesidad es un problema grave que representa una alta carga para la salud de las personas y sus familias: genera una mayor discapacidad, pérdida de productividad, aumento de enfermedades y muerte prematura. Tradicionalmente, se ha considerado que la patogénesis de la obesidad es el resultado de un desbalance entre la ingesta y el gasto de energía que favorece el aumento de peso. Sin embargo, corresponde a una interacción más compleja entre factores genéticos, ambientales y conductuales.Varios estudios se han centrado en los principios de la termodinámica aplicados a los sensores de energía del cuerpo humano, como activadores de la respuesta metabólica frente a períodos de ayuno y sobrealimentación, para determinar fenotipos metabólicos o individuos que son más susceptibles a variaciones en el peso corporal. La identificación de fenotipos metabólicos permitiría establecer estrategias preventivas o terapias personalizadas para controlar el exceso de peso, favorecer la recuperación de un peso saludable y evitar o controlar los problemas de salud asociados.El objetivo de esta revisión es analizar las características del fenotipo metabólico ahorrador, y los mecanismos fisiológicos involucrados, que permitan proyectar futuras estrategias individualizadas para la prevención y/o tratamiento de pacientes con sobrepeso u obesidad.Obesity is a serious problem that represents a sizeable burden on the health of individuals and their families: it generates greater disability, reduces productivity, increases disease and premature death. Traditionally, the pathogenesis of obesity has been thought to be the result of an imbalance between energy intake and expenditure that favors weight gain. However, it corresponds to a more complex interaction between genetic, environmental, and behavioral factors.Several studies have focused on thermodynamic principles applied to energy sensors in humans that trigger different metabolic responses when exposed to periods of both fasting and overfeeding. Such studies help determine the metabolic phenotypes of individuals who are more susceptible to variations in body weight. The identification of metabolic phenotypes may aid in the development of preventive strategies, such as personalized therapies to control excess weight, favor the recovery of a healthy weight and avoid or control associated health problems.The aim of this review is to analyze the characteristics of the thrifty metabolic phenotype, and the physiological mechanisms involved, that will allow the design of future individualized strategies for the prevention and/or treatment of patients with overweight or obesity." @default.
- W4250136207 created "2022-05-12" @default.
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- W4250136207 date "2004-12-01" @default.
- W4250136207 modified "2023-09-25" @default.
- W4250136207 title "Nutrition in Critical Care" @default.
- W4250136207 doi "https://doi.org/10.1016/s0899-5885(04)00072-3" @default.
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