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• W4250147191 abstract "We thank Dolz-Marco and associates for their interest in and comments on our recent article on the natural course of adult-onset foveomacular vitelliform dystrophy (AOFVD) by spectral-domain optical coherence tomography. 1 Querques G. Forte R. Querques L. Massamba N. Souied E.H. Natural course of adult-onset foveomacular vitelliform dystrophy: a spectral-domain optical coherence tomography analysis. Am J Ophthalmol. 2011; 152: 304-313 Abstract Full Text Full Text PDF PubMed Scopus (48) Google Scholar The clinical features of AOFVD were described first by Gass in 1974. 2 Gass J.D.M. A clinicopathologic study of a peculiar foveo-macular dystrophy. Trans Am Ophthalmol Soc. 1974; 72: 139-156 PubMed Google Scholar The disease then was characterized by a late-onset (between 30 and 50 years of age) solitary, round or oval, elevated, yellow, subretinal lesion of the fovea, ranging from one-third to 1 disk diameter in size and often accompanied by a central pigmented spot. 2 Gass J.D.M. A clinicopathologic study of a peculiar foveo-macular dystrophy. Trans Am Ophthalmol Soc. 1974; 72: 139-156 PubMed Google Scholar Since 1974, several cases of AOFVD have been reported in multiple clinical series. 3 Renner A.B. Tillack H. Kraus H. et al. Morphology and functional characteristics in adult vitelliform macular dystrophy. Retina. 2004; 24: 929-939 Crossref PubMed Scopus (69) Google Scholar These series revealed high variability in the appearance and progression of AOFVD, and unfortunately, have generated a number of different terms and abbreviations for this disease and have supported the idea that it may represent a heterogeneous group of disorders with variable clinical features. 3 Renner A.B. Tillack H. Kraus H. et al. Morphology and functional characteristics in adult vitelliform macular dystrophy. Retina. 2004; 24: 929-939 Crossref PubMed Scopus (69) Google Scholar These undefined features may have led Dolz-Marco and associates to misdiagnose as AOFVD the series of 25 eyes investigated by spectral-domain optical coherence tomography to whom they refer. In fact, it should be noted that, as recently reported by Meunier and associates, age of onset is the only major criterion to distinguish juvenile vitelliform macular dystrophy from AOFVD (2 diseases otherwise clinically indistinguishable). 4 Meunier I. Sénéchal A. Dhaenens C.M. et al. Systematic screening of BEST1 and PRPH2 in juvenile and adult vitelliform macular dystrophies: a rationale for molecular analysis. Ophthalmology. 2011; 118: 1130-1136 Abstract Full Text Full Text PDF PubMed Scopus (50) Google Scholar Thus, it is not surprising that a similar progression, through different stages, may account for both vitelliform macular dystrophy and AOFVD, as described in our article. 1 Querques G. Forte R. Querques L. Massamba N. Souied E.H. Natural course of adult-onset foveomacular vitelliform dystrophy: a spectral-domain optical coherence tomography analysis. Am J Ophthalmol. 2011; 152: 304-313 Abstract Full Text Full Text PDF PubMed Scopus (48) Google Scholar Natural Course of Adult-Onset Foveomacular Vitelliform Dystrophy: A Spectral-Domain Optical Coherence Tomography AnalysisAmerican Journal of OphthalmologyVol. 153Issue 2PreviewWe read with great interest the article by Querques and associates describing progressive stages in patients with presumed adult-onset foveomacular vitelliform dystrophy (AOFVD): vitelliform, pseudohypopyon, vitelliruptive, and atrophic.1 The authors also noted a significant decrease in visual acuity in eyes showing progression through these stages. Full-Text PDF" @default.
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• W4250147191 doi "https://doi.org/10.1016/j.ajo.2011.11.026" @default.
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