Matches in SemOpenAlex for { <https://semopenalex.org/work/W4250186772> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4250186772 endingPage "208" @default.
- W4250186772 startingPage "208" @default.
- W4250186772 abstract "The oxidative denitrification of the antitumour agent hydroxyguanidine (HOG) has been investigated by radiolysis methods and EPR spectroscopy. The azide radical (N3), a model one-electron oxidant, reacts with HOG with the rate constant 5.1 × 109 dm3 mol−1 s−1 to yield the guanidino carbon-centred radical (HOG) which rapidly eliminates nitric oxide (k = 3.1 × 103 s−1) with the concomitant formation of urea. The HOG undergoes conjugation with molecular oxygen to form a peroxyl radical (HOGOO) with a rate constant 8.8 × 108 dm3 mol−1 s−1. The HOGOO radical also eliminates nitric oxide but may act as a precurser to the peroxynitrite (ONOO−) ion. The oxidation of HOG by the dibromide radical (Br2̇−) was found to release nitric oxide with a yield of 95% relative to Br2̇− as determined from the combined yields of inorganic nitrite, nitrate and a HOG/nitric oxide-adduct. This study provides a possible mechanistic basis for the oxidative denitrification of HOG which may contribute to the observed toxicity of the drug both in vitro and in vivo and for the oxidation of nonphysiological hydroxyguanidines to NO via nitric oxide synthase-independent pathways." @default.
- W4250186772 created "2022-05-12" @default.
- W4250186772 date "1998-01-01" @default.
- W4250186772 modified "2023-09-26" @default.
- W4250186772 title "Product review" @default.
- W4250186772 doi "https://doi.org/10.1016/s0891-5849(97)00208-6" @default.
- W4250186772 hasPublicationYear "1998" @default.
- W4250186772 type Work @default.
- W4250186772 citedByCount "0" @default.
- W4250186772 crossrefType "journal-article" @default.
- W4250186772 hasConcept C108204754 @default.
- W4250186772 hasConcept C134121241 @default.
- W4250186772 hasConcept C139066938 @default.
- W4250186772 hasConcept C13965031 @default.
- W4250186772 hasConcept C178790620 @default.
- W4250186772 hasConcept C181199279 @default.
- W4250186772 hasConcept C185592680 @default.
- W4250186772 hasConcept C191897082 @default.
- W4250186772 hasConcept C192562407 @default.
- W4250186772 hasConcept C2776179834 @default.
- W4250186772 hasConcept C2776384668 @default.
- W4250186772 hasConcept C2778784160 @default.
- W4250186772 hasConcept C2780795997 @default.
- W4250186772 hasConcept C2780997848 @default.
- W4250186772 hasConcept C519581460 @default.
- W4250186772 hasConcept C66887884 @default.
- W4250186772 hasConcept C75473681 @default.
- W4250186772 hasConceptScore W4250186772C108204754 @default.
- W4250186772 hasConceptScore W4250186772C134121241 @default.
- W4250186772 hasConceptScore W4250186772C139066938 @default.
- W4250186772 hasConceptScore W4250186772C13965031 @default.
- W4250186772 hasConceptScore W4250186772C178790620 @default.
- W4250186772 hasConceptScore W4250186772C181199279 @default.
- W4250186772 hasConceptScore W4250186772C185592680 @default.
- W4250186772 hasConceptScore W4250186772C191897082 @default.
- W4250186772 hasConceptScore W4250186772C192562407 @default.
- W4250186772 hasConceptScore W4250186772C2776179834 @default.
- W4250186772 hasConceptScore W4250186772C2776384668 @default.
- W4250186772 hasConceptScore W4250186772C2778784160 @default.
- W4250186772 hasConceptScore W4250186772C2780795997 @default.
- W4250186772 hasConceptScore W4250186772C2780997848 @default.
- W4250186772 hasConceptScore W4250186772C519581460 @default.
- W4250186772 hasConceptScore W4250186772C66887884 @default.
- W4250186772 hasConceptScore W4250186772C75473681 @default.
- W4250186772 hasIssue "1" @default.
- W4250186772 hasLocation W42501867721 @default.
- W4250186772 hasOpenAccess W4250186772 @default.
- W4250186772 hasPrimaryLocation W42501867721 @default.
- W4250186772 hasRelatedWork W2030096754 @default.
- W4250186772 hasRelatedWork W2038615667 @default.
- W4250186772 hasRelatedWork W2062163549 @default.
- W4250186772 hasRelatedWork W2087532251 @default.
- W4250186772 hasRelatedWork W2124897287 @default.
- W4250186772 hasRelatedWork W2587175364 @default.
- W4250186772 hasRelatedWork W2803482100 @default.
- W4250186772 hasRelatedWork W2951799260 @default.
- W4250186772 hasRelatedWork W3116329321 @default.
- W4250186772 hasRelatedWork W4210772757 @default.
- W4250186772 hasVolume "24" @default.
- W4250186772 isParatext "false" @default.
- W4250186772 isRetracted "false" @default.
- W4250186772 workType "article" @default.