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- W4250216754 abstract "This chapter discusses the properties of colchicine used for the treatment of gout. Colchicine's other biological characteristics—namely, its highly specific association with microtubule proteins and its effects on basic cell functions, such as mitosis, secretion, cell morphology, motility, intracellular transport of macromolecules, microtubular assembly, and mitogenic activation—make it a widely applicable compound for use medicinally and for biochemical and biomedical research. Colchicine is a pale yellow and amorphous powder; it is odorless and darkens on exposure to light. The chapter discusses the physical properties of colchicine, such as nuclear magnetic resonance (NMR) spectra, infrared spectrum, proton NMR spectrum, carbon-13 NMR spectrum, ultraviolet absorption spectrum, and mass spectrum. Anhydrous colchicine decreases in solubility with increasing temperature. The reverse occurs with the sesquihydrate. Colchicine is the medicinally active component in Colchicum autumnale L (Liliaceae) as well as more than fifty species of the Liliaceae family. The crystal structure, conformation, bond distances, bond angles, and atomic coordinates of colchicine are presented in the chapter." @default.
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- W4250216754 date "1981-01-01" @default.
- W4250216754 modified "2023-10-16" @default.
- W4250216754 title "Colchicine" @default.
- W4250216754 doi "https://doi.org/10.1016/s0099-5428(08)60641-3" @default.
- W4250216754 hasPublicationYear "1981" @default.
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