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- W4250223808 abstract "In conclusion, each of the commentators is an investigator in this field as well. Are their ‘comments’ more objective than our meta-analysis? We could have predicted previously that Dr. Max would respond negatively and Dr. Turner and Dr. Kerns would respond positively to our review, and this is exactly what happened. One could say that our response to this exercise is potentially nihilistic. In reviewing such studies we cannot conclude anything because anyone doing a study is inherently biased and so would anyone be. Ultimately, the rules of evaluation themselves and strict adherence to them are what should prevent this problem, as we have endeavored to achieve here. One could still suggest that we ourselves are, nevertheless, biased, since we conducted one trial of trazodone demonstrating no therapeutic effect and published one negative prior review article. However, such an argument could be posed regardless of the investigator's particular prior history in the field. The final decision, therefore, resides with you—the clinician or researcher reading this article. It is your job, in the end, to interpret what we have all written here, to evaluate our relative objectivity, and to arrive at your own conclusions to apply to your practice or research, or both. Certain methods can be used in order to enhance the likelihood of only applying results truly relevant to the specific clinical situation you encounter. For example, clinical decision analysis may be employed to aid in exploring the various outcomes along the decision-making process.21 Hopefully, the issues presented here about the place for antidepressant drugs in the treatment of chronic, benign pain syndromes will be evaluated by you against the impact of multiple other interventions, both pharmacological and nonpharmacological, as well as the impact of a multidisciplinary pain program in the treatment of your patients with specific pain syndromes. The outcomes of such decision analyses may then have encouraged you to embrace such analytical thinking for your routine clinical needs. If so, then this forum will have accomplished its end." @default.
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- W4250223808 title "Rebuttal" @default.
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