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- W4250247235 abstract "93 Transplant coronary arteriopathy is the leading cause of allograft failure following cardiac transplantation. Serial coronary angiograms have been used as the gold standard for detection of this process, requiring annual invasive procedures. We have shown a relationship between depletion of arteriolar smooth muscle tissue plasminogen activator and transplant coronary arteriopathy. This process may therefore result in increased fibrin formation. Fibrinopeptide A (FPA) levels correlate with in vivo fibrin formation and are increased in patients with intracoronary thrombus formation. Since the presence and severity of transplant coronary arteriopathy is associated with vascular fibrin deposition within the allografts, we asked if FPA levels were increased in recipients who developed the disease. Methods: Urine FPA levels of 33 consecutive post cardiac transplantation patients were evaluated during routine outpatient visits. A predetermined FPA level greater than 3.2 ng/mg creatinine was considered abnormal. Patients' coronary cineangiograms within the 6 months enrollment period were interpreted by an investigator without prior knowledge of clinical history and FPA levels. Transplant coronary arteriopathy was semiquantitated as mild, moderate or severe. Results: Patients in the study had a mean age of 53 years, 76% were males, and they had 5.6 years mean follow up after transplantation. Twenty six patients had normal coronary arteries or only mild coronary arteriopathy on angiography while 7 patients had moderate or severe coronary arteriopathy. Mean urine FPA in patients with normal coronary arteries or with only mild coronary arteriopathy was 1.0 ng/mg creatinine compared to 5.6 ng/mg creatinine in patients with moderate or severe coronary arteriopathy (p=0.035). None of the 26 patients with normal coronary arteries or mild coronary arteriopathy had abnormal FPA levels, compared to 4 of 7 (58%) patients with moderate or severe coronary arteriopathy (p=0.001). Conclusions: Patients with moderate or severe transplant coronary arteriopathy have higher urine FPA levels and thus spot urine FPA measurements may be useful as a non invasive marker of transplant coronary arteriopathy." @default.
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- W4250247235 date "1998-06-01" @default.
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- W4250247235 title "USEFULNESS OF URINE FIBRINOPEPTIDE A LEVELS IN DETECTING TRANSPLANT CORONARY ARTERIOPATHY" @default.
- W4250247235 doi "https://doi.org/10.1097/00007890-199806270-00112" @default.
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