FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4250249694> ?p ?o ?g. }

• W4250249694 endingPage "1267" @default.
• W4250249694 startingPage "1262" @default.
• W4250249694 abstract "Alzheimer’s disease, one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by declines in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is maintaining levels of acetylcholine by inhibiting acetylcholinesterase (AChE). In the present study, coumarin derivatives were designed and synthesized as AChE inhibitors based on the lead structure of scopoletin. Of those synthesized, pyrrolidine-substituted coumarins 3b and 3f showed ca. 160-fold higher AChE inhibitory activities than scopoletin. These compounds also ameliorated scopolamine-induced memory deficit in mice when administered orally at the dose of 1 and 2 mg/kg." @default.
• W4250249694 created "2022-05-12" @default.
• W4250249694 creator A5024300611 @default.
• W4250249694 creator A5034944739 @default.
• W4250249694 creator A5035383340 @default.
• W4250249694 creator A5040124447 @default.
• W4250249694 creator A5055676243 @default.
• W4250249694 date "2014-02-01" @default.
• W4250249694 modified "2023-09-26" @default.
• W4250249694 title "Synthesis of aminoalkyl-substituted coumarin derivatives as acetylcholinesterase inhibitors" @default.
• W4250249694 cites W1971048984 @default.
• W4250249694 cites W1974392545 @default.
• W4250249694 cites W1992981307 @default.
• W4250249694 cites W2021312811 @default.
• W4250249694 cites W2052613003 @default.
• W4250249694 cites W2053936304 @default.
• W4250249694 cites W2060174511 @default.
• W4250249694 cites W2070448139 @default.
• W4250249694 cites W2077327357 @default.
• W4250249694 cites W2084253896 @default.
• W4250249694 cites W2091263760 @default.
• W4250249694 cites W2091425658 @default.
• W4250249694 cites W2107327698 @default.
• W4250249694 cites W2122320288 @default.
• W4250249694 cites W2137777161 @default.
• W4250249694 cites W4242055924 @default.
• W4250249694 cites W79754231 @default.
• W4250249694 doi "https://doi.org/10.1016/j.bmc.2014.01.010" @default.
• W4250249694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24485122" @default.
• W4250249694 hasPublicationYear "2014" @default.
• W4250249694 type Work @default.
• W4250249694 citedByCount "23" @default.
• W4250249694 countsByYear W42502496942014 @default.
• W4250249694 countsByYear W42502496942015 @default.
• W4250249694 countsByYear W42502496942016 @default.
• W4250249694 countsByYear W42502496942017 @default.
• W4250249694 countsByYear W42502496942018 @default.
• W4250249694 countsByYear W42502496942019 @default.
• W4250249694 countsByYear W42502496942021 @default.
• W4250249694 countsByYear W42502496942022 @default.
• W4250249694 countsByYear W42502496942023 @default.
• W4250249694 crossrefType "journal-article" @default.
• W4250249694 hasAuthorship W4250249694A5024300611 @default.
• W4250249694 hasAuthorship W4250249694A5034944739 @default.
• W4250249694 hasAuthorship W4250249694A5035383340 @default.
• W4250249694 hasAuthorship W4250249694A5040124447 @default.
• W4250249694 hasAuthorship W4250249694A5055676243 @default.
• W4250249694 hasConcept C126322002 @default.
• W4250249694 hasConcept C142724271 @default.
• W4250249694 hasConcept C178790620 @default.
• W4250249694 hasConcept C181199279 @default.
• W4250249694 hasConcept C185592680 @default.
• W4250249694 hasConcept C204787440 @default.
• W4250249694 hasConcept C2775910092 @default.
• W4250249694 hasConcept C2776332859 @default.
• W4250249694 hasConcept C2778816929 @default.
• W4250249694 hasConcept C2778851528 @default.
• W4250249694 hasConcept C2779056891 @default.
• W4250249694 hasConcept C2779059548 @default.
• W4250249694 hasConcept C2779134260 @default.
• W4250249694 hasConcept C2779483572 @default.
• W4250249694 hasConcept C2780473948 @default.
• W4250249694 hasConcept C2780904820 @default.
• W4250249694 hasConcept C2781338262 @default.
• W4250249694 hasConcept C31896038 @default.
• W4250249694 hasConcept C55493867 @default.
• W4250249694 hasConcept C71240020 @default.
• W4250249694 hasConcept C71924100 @default.
• W4250249694 hasConcept C98274493 @default.
• W4250249694 hasConceptScore W4250249694C126322002 @default.
• W4250249694 hasConceptScore W4250249694C142724271 @default.
• W4250249694 hasConceptScore W4250249694C178790620 @default.
• W4250249694 hasConceptScore W4250249694C181199279 @default.
• W4250249694 hasConceptScore W4250249694C185592680 @default.
• W4250249694 hasConceptScore W4250249694C204787440 @default.
• W4250249694 hasConceptScore W4250249694C2775910092 @default.
• W4250249694 hasConceptScore W4250249694C2776332859 @default.
• W4250249694 hasConceptScore W4250249694C2778816929 @default.
• W4250249694 hasConceptScore W4250249694C2778851528 @default.
• W4250249694 hasConceptScore W4250249694C2779056891 @default.
• W4250249694 hasConceptScore W4250249694C2779059548 @default.
• W4250249694 hasConceptScore W4250249694C2779134260 @default.
• W4250249694 hasConceptScore W4250249694C2779483572 @default.
• W4250249694 hasConceptScore W4250249694C2780473948 @default.
• W4250249694 hasConceptScore W4250249694C2780904820 @default.
• W4250249694 hasConceptScore W4250249694C2781338262 @default.
• W4250249694 hasConceptScore W4250249694C31896038 @default.
• W4250249694 hasConceptScore W4250249694C55493867 @default.
• W4250249694 hasConceptScore W4250249694C71240020 @default.
• W4250249694 hasConceptScore W4250249694C71924100 @default.
• W4250249694 hasConceptScore W4250249694C98274493 @default.
• W4250249694 hasFunder F4320322120 @default.
• W4250249694 hasFunder F4320322349 @default.
• W4250249694 hasIssue "4" @default.
• W4250249694 hasLocation W42502496941 @default.
• W4250249694 hasLocation W42502496942 @default.
• W4250249694 hasOpenAccess W4250249694 @default.
• W4250249694 hasPrimaryLocation W42502496941 @default.

• next