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- W4250388210 abstract "Thiobenzyl benzyloxycarbonyl- l -lysinate (Z-Lys-SBzl), a substrate for trypsin-likeproteases, was synthesized. In the presence of 5,5′-dithiobis(2-nitrobenzoic acid) the hydrolysis of the thiol ester by trypsin-like enzymes provides a continuous colorimetric assay with a sensitivity comparable to the best fluorometric substrates. Z-Lys-SBzl is readily synthesized in good yield, is water soluble, and has a low rate of spontaneous hydrolysis even at pH 8.0. This assay procedure has been routinely used with urokinase, human urinary and human plasma kallikrein, thrombin, plasmin, β -trypsin, factor Xa, and crotalase. Levels of detection of these enzymes are in the range 10 −14 to 10 −13 mol." @default.
- W4250388210 created "2022-05-12" @default.
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- W4250388210 date "1979-02-01" @default.
- W4250388210 modified "2023-09-30" @default.
- W4250388210 title "Thiobenzyl benzyloxycarbonyl-l-lysinate, substrate for a sensitive colorimetric assay for trypsin-like enzymes1" @default.
- W4250388210 doi "https://doi.org/10.1016/s0003-2697(79)80070-6" @default.
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