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- W4250459909 abstract "Of 491 patients with systemic lupus erythematosus (SLE), 249 (51%) are known dead. From 1950 to 1955, 15 of 57 patients (26%) died of central nervous system (CNS) damage and an equal number died of uremia. High-dosage corticosteroid therapy for CNS involvement was introduced in 1956. From 1956 to 1962, only 11 of 100 patients died of CNS involvement and 36% of the patients died of uremia. During the past ten years, with high-dose corticosteroid therapy, dialysis, and renal transplantation, only 7 of 92 patients (8%) died of CNS damage and 14% of the patients died of uremia. Death from infections, vascular complications, and malignant neoplasms occurred more frequently. The changes were significant (<i>P</i><.0001). Black patients did not have a more malignant course than others. The median time from diagnosis to death in 79 blacks was 3.5 years; this was identical in 170 other patients." @default.
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- W4250459909 date "1974-03-25" @default.
- W4250459909 modified "2023-10-17" @default.
- W4250459909 title "Duration and death in systemic lupus erythematosus. An analysis of 249 cases" @default.
- W4250459909 doi "https://doi.org/10.1001/jama.227.12.1399" @default.
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