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- W4250495514 abstract "Isoproteins such as proteolipid protein (PLP) are synthesized by oligodendrocytes as the two major integral proteins of myelin membranes of the central nervous system (CNS). This chapter presents a study in which the phenotype of homozygous double PLP–/–MBP–/– (myelin basic protein) mutant mice ameliorated shiverer symptoms and rare seizures. They showed normal development and no premature death of oligodendrocytes, had a normal reproduction rate, and a lifespan of at least 18 months. Light and electron microscopy revealed that oligodendrocytes of PLP/MBP-deficient mice were able to ensheath many CNS axons with an atypical myelin containing only few lamellae which in contrast to the myelin of shiverer mice, spirally wrapped axons with a larger diameter. The peripheral nervous system (PNS) myelin of the double mutant exhibited a normal periodic structure like the nearly normal PNS of MBP-deficient mice." @default.
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- W4250495514 date "1998-01-01" @default.
- W4250495514 modified "2023-09-27" @default.
- W4250495514 title "PLP" @default.
- W4250495514 doi "https://doi.org/10.1016/b978-012466044-1/50483-x" @default.
- W4250495514 hasPublicationYear "1998" @default.
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