Matches in SemOpenAlex for { <https://semopenalex.org/work/W4250674033> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4250674033 endingPage "434" @default.
- W4250674033 startingPage "434" @default.
- W4250674033 abstract "Wilms tumor is the most common pediatric renal malignancy and there is a clinical need for a molecular biomarker to assess treatment response and predict relapse. The known mutated genes in this tumor type show low mutation frequencies, whereas aberrant methylation at 11p15 is by far the most common aberration. We therefore analyzed the epigenome, rather than the genome, to identify ubiquitous tumor-specific biomarkers. Methylome analysis of matched normal kidney and Wilms tumor identifies 309 preliminary methylation variable positions which we translate into three differentially methylated regions (DMR) for use as tumor-specific biomarkers. Using two novel algorithms we show that these three DMRs are not confounded by cell type composition. We further show that these DMRs are not methylated in embryonic blastema but are intermediately methylated in Wilms tumor precursor lesions. We validate the biomarker DMRs using two independent sample sets of normal kidney and Wilms tumor and seven Wilms tumor histological subtypes, achieving 100% and 98% correct classification, respectively. As proof-of-principle for clinical utility, we successfully use biomarker DMR-2 in a pilot analysis of cell-free circulating DNA to monitor tumor response during treatment in ten patients. These findings define the most common methylated regions in Wilms tumor known to date which are not associated with their embryonic origin or precursor stage. We show that this tumor-specific methylated DNA is released into the blood circulation where it can be detected non-invasively showing potential for clinical utility." @default.
- W4250674033 created "2022-05-12" @default.
- W4250674033 creator A5010670393 @default.
- W4250674033 creator A5010741060 @default.
- W4250674033 creator A5016790809 @default.
- W4250674033 creator A5027792746 @default.
- W4250674033 creator A5030821765 @default.
- W4250674033 creator A5033556679 @default.
- W4250674033 creator A5035410237 @default.
- W4250674033 creator A5037501835 @default.
- W4250674033 creator A5049029911 @default.
- W4250674033 creator A5069561562 @default.
- W4250674033 creator A5072064334 @default.
- W4250674033 date "2014-01-01" @default.
- W4250674033 modified "2023-09-26" @default.
- W4250674033 title "Methylome analysis identifies a Wilms tumor epigenetic biomarker detectable in blood" @default.
- W4250674033 doi "https://doi.org/10.1186/preaccept-1285638141135215" @default.
- W4250674033 hasPublicationYear "2014" @default.
- W4250674033 type Work @default.
- W4250674033 citedByCount "0" @default.
- W4250674033 crossrefType "journal-article" @default.
- W4250674033 hasAuthorship W4250674033A5010670393 @default.
- W4250674033 hasAuthorship W4250674033A5010741060 @default.
- W4250674033 hasAuthorship W4250674033A5016790809 @default.
- W4250674033 hasAuthorship W4250674033A5027792746 @default.
- W4250674033 hasAuthorship W4250674033A5030821765 @default.
- W4250674033 hasAuthorship W4250674033A5033556679 @default.
- W4250674033 hasAuthorship W4250674033A5035410237 @default.
- W4250674033 hasAuthorship W4250674033A5037501835 @default.
- W4250674033 hasAuthorship W4250674033A5049029911 @default.
- W4250674033 hasAuthorship W4250674033A5069561562 @default.
- W4250674033 hasAuthorship W4250674033A5072064334 @default.
- W4250674033 hasBestOaLocation W42506740331 @default.
- W4250674033 hasConcept C104317684 @default.
- W4250674033 hasConcept C117717151 @default.
- W4250674033 hasConcept C142724271 @default.
- W4250674033 hasConcept C150194340 @default.
- W4250674033 hasConcept C154253233 @default.
- W4250674033 hasConcept C190727270 @default.
- W4250674033 hasConcept C2775999222 @default.
- W4250674033 hasConcept C2781197716 @default.
- W4250674033 hasConcept C33288867 @default.
- W4250674033 hasConcept C41091548 @default.
- W4250674033 hasConcept C502942594 @default.
- W4250674033 hasConcept C54355233 @default.
- W4250674033 hasConcept C71924100 @default.
- W4250674033 hasConcept C86803240 @default.
- W4250674033 hasConceptScore W4250674033C104317684 @default.
- W4250674033 hasConceptScore W4250674033C117717151 @default.
- W4250674033 hasConceptScore W4250674033C142724271 @default.
- W4250674033 hasConceptScore W4250674033C150194340 @default.
- W4250674033 hasConceptScore W4250674033C154253233 @default.
- W4250674033 hasConceptScore W4250674033C190727270 @default.
- W4250674033 hasConceptScore W4250674033C2775999222 @default.
- W4250674033 hasConceptScore W4250674033C2781197716 @default.
- W4250674033 hasConceptScore W4250674033C33288867 @default.
- W4250674033 hasConceptScore W4250674033C41091548 @default.
- W4250674033 hasConceptScore W4250674033C502942594 @default.
- W4250674033 hasConceptScore W4250674033C54355233 @default.
- W4250674033 hasConceptScore W4250674033C71924100 @default.
- W4250674033 hasConceptScore W4250674033C86803240 @default.
- W4250674033 hasIssue "8" @default.
- W4250674033 hasLocation W42506740331 @default.
- W4250674033 hasLocation W42506740332 @default.
- W4250674033 hasLocation W42506740333 @default.
- W4250674033 hasLocation W42506740334 @default.
- W4250674033 hasOpenAccess W4250674033 @default.
- W4250674033 hasPrimaryLocation W42506740331 @default.
- W4250674033 hasRelatedWork W1698395555 @default.
- W4250674033 hasRelatedWork W1984438312 @default.
- W4250674033 hasRelatedWork W2142309127 @default.
- W4250674033 hasRelatedWork W2883458476 @default.
- W4250674033 hasRelatedWork W2916077215 @default.
- W4250674033 hasRelatedWork W2944764859 @default.
- W4250674033 hasRelatedWork W2963862309 @default.
- W4250674033 hasRelatedWork W3087290841 @default.
- W4250674033 hasRelatedWork W3111017817 @default.
- W4250674033 hasRelatedWork W4293795062 @default.
- W4250674033 hasVolume "15" @default.
- W4250674033 isParatext "false" @default.
- W4250674033 isRetracted "false" @default.
- W4250674033 workType "article" @default.