FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4250684226> ?p ?o ?g. }

• W4250684226 endingPage "8318" @default.
• W4250684226 startingPage "8309" @default.
• W4250684226 abstract "Abstract We report on the development of a monitoring test for recurrent breast cancer, using metabolite-profiling methods. Using a combination of nuclear magnetic resonance (NMR) and two-dimensional gas chromatography–mass spectrometry (GC×GC-MS) methods, we analyzed the metabolite profiles of 257 retrospective serial serum samples from 56 previously diagnosed and surgically treated breast cancer patients. One hundred sixteen of the serial samples were from 20 patients with recurrent breast cancer, and 141 samples were from 36 patients with no clinical evidence of the disease during ∼6 years of sample collection. NMR and GC×GC-MS data were analyzed by multivariate statistical methods to compare identified metabolite signals between the recurrence samples and those with no evidence of disease. Eleven metabolite markers (seven from NMR and four from GC×GC-MS) were shortlisted from an analysis of all patient samples by using logistic regression and 5-fold cross-validation. A partial least squares discriminant analysis model built using these markers with leave-one-out cross-validation provided a sensitivity of 86% and a specificity of 84% (area under the receiver operating characteristic curve = 0.88). Strikingly, 55% of the patients could be correctly predicted to have recurrence 13 months (on average) before the recurrence was clinically diagnosed, representing a large improvement over the current breast cancer–monitoring assay CA 27.29. To the best of our knowledge, this is the first study to develop and prevalidate a prediction model for early detection of recurrent breast cancer based on metabolic profiles. In particular, the combination of two advanced analytical methods, NMR and MS, provides a powerful approach for the early detection of recurrent breast cancer. Cancer Res; 70(21); 8309–18. ©2010 AACR." @default.
• W4250684226 created "2022-05-12" @default.
• W4250684226 creator A5023366064 @default.
• W4250684226 creator A5028596148 @default.
• W4250684226 creator A5041345883 @default.
• W4250684226 creator A5042812463 @default.
• W4250684226 creator A5077632362 @default.
• W4250684226 creator A5087103290 @default.
• W4250684226 creator A5090600155 @default.
• W4250684226 date "2010-10-31" @default.
• W4250684226 modified "2023-10-16" @default.
• W4250684226 title "Early Detection of Recurrent Breast Cancer Using Metabolite Profiling" @default.
• W4250684226 cites W1566210456 @default.
• W4250684226 cites W1826672661 @default.
• W4250684226 cites W1965417976 @default.
• W4250684226 cites W1967278952 @default.
• W4250684226 cites W1968593126 @default.
• W4250684226 cites W1968813633 @default.
• W4250684226 cites W1976841916 @default.
• W4250684226 cites W1978417221 @default.
• W4250684226 cites W1992414896 @default.
• W4250684226 cites W2003946261 @default.
• W4250684226 cites W2007352226 @default.
• W4250684226 cites W2009765233 @default.
• W4250684226 cites W2014535644 @default.
• W4250684226 cites W2018544102 @default.
• W4250684226 cites W2020182172 @default.
• W4250684226 cites W2062090250 @default.
• W4250684226 cites W2065236043 @default.
• W4250684226 cites W2075373098 @default.
• W4250684226 cites W2092155681 @default.
• W4250684226 cites W2098945202 @default.
• W4250684226 cites W2100463095 @default.
• W4250684226 cites W2101995865 @default.
• W4250684226 cites W2113841018 @default.
• W4250684226 cites W2117305280 @default.
• W4250684226 cites W2117873981 @default.
• W4250684226 cites W2122929031 @default.
• W4250684226 cites W2134326673 @default.
• W4250684226 cites W2134732827 @default.
• W4250684226 cites W2139782977 @default.
• W4250684226 cites W2147240679 @default.
• W4250684226 cites W2155680682 @default.
• W4250684226 cites W2165681080 @default.
• W4250684226 cites W2170481258 @default.
• W4250684226 cites W2173393481 @default.
• W4250684226 cites W2324291392 @default.
• W4250684226 cites W2489837100 @default.
• W4250684226 doi "https://doi.org/10.1158/0008-5472.can-10-1319" @default.
• W4250684226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20959483" @default.
• W4250684226 hasPublicationYear "2010" @default.
• W4250684226 type Work @default.
• W4250684226 citedByCount "225" @default.
• W4250684226 countsByYear W42506842262012 @default.
• W4250684226 countsByYear W42506842262013 @default.
• W4250684226 countsByYear W42506842262014 @default.
• W4250684226 countsByYear W42506842262015 @default.
• W4250684226 countsByYear W42506842262016 @default.
• W4250684226 countsByYear W42506842262017 @default.
• W4250684226 countsByYear W42506842262018 @default.
• W4250684226 countsByYear W42506842262019 @default.
• W4250684226 countsByYear W42506842262020 @default.
• W4250684226 countsByYear W42506842262021 @default.
• W4250684226 countsByYear W42506842262022 @default.
• W4250684226 countsByYear W42506842262023 @default.
• W4250684226 crossrefType "journal-article" @default.
• W4250684226 hasAuthorship W4250684226A5023366064 @default.
• W4250684226 hasAuthorship W4250684226A5028596148 @default.
• W4250684226 hasAuthorship W4250684226A5041345883 @default.
• W4250684226 hasAuthorship W4250684226A5042812463 @default.
• W4250684226 hasAuthorship W4250684226A5077632362 @default.
• W4250684226 hasAuthorship W4250684226A5087103290 @default.
• W4250684226 hasAuthorship W4250684226A5090600155 @default.
• W4250684226 hasBestOaLocation W42506842261 @default.
• W4250684226 hasConcept C121608353 @default.
• W4250684226 hasConcept C126322002 @default.
• W4250684226 hasConcept C143998085 @default.
• W4250684226 hasConcept C151956035 @default.
• W4250684226 hasConcept C185592680 @default.
• W4250684226 hasConcept C21565614 @default.
• W4250684226 hasConcept C2777477808 @default.
• W4250684226 hasConcept C2994400308 @default.
• W4250684226 hasConcept C38180746 @default.
• W4250684226 hasConcept C43617362 @default.
• W4250684226 hasConcept C530470458 @default.
• W4250684226 hasConcept C58471807 @default.
• W4250684226 hasConcept C71924100 @default.
• W4250684226 hasConceptScore W4250684226C121608353 @default.
• W4250684226 hasConceptScore W4250684226C126322002 @default.
• W4250684226 hasConceptScore W4250684226C143998085 @default.
• W4250684226 hasConceptScore W4250684226C151956035 @default.
• W4250684226 hasConceptScore W4250684226C185592680 @default.
• W4250684226 hasConceptScore W4250684226C21565614 @default.
• W4250684226 hasConceptScore W4250684226C2777477808 @default.
• W4250684226 hasConceptScore W4250684226C2994400308 @default.
• W4250684226 hasConceptScore W4250684226C38180746 @default.
• W4250684226 hasConceptScore W4250684226C43617362 @default.
• W4250684226 hasConceptScore W4250684226C530470458 @default.

• next