Matches in SemOpenAlex for { <https://semopenalex.org/work/W4250734902> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W4250734902 abstract "Tumours shed cells over the course of its development and these cells migrate to the bloodstream after overcoming multiple barriers at the cellular and tissue level. Such cells are known as circulating tumour cells (CTCs). Thus, opportunities exist for using a simple blood draw to help isolate the circulating tumour cells that could inform cancer treatment. Specifically, circulating tumour cells could be isolated from the blood, concentrated and sent for DNA sequencing to identify the mutational signature of the cells. If circulating tumour cells are sequenced at the population rather than single cell level, the information obtained would inform the oncologist about the aggregate mutational pattern of a cancer in a patient. If circulating tumour cells are from a multitude of cancers in a patient whose disease has metastasized, the aggregate profile would remain useful in identifying the mutations present and possible drugs that could be used. On the other hand, if single cell DNA sequencing is used, circulating tumour cells could illuminate, through phylogenetic clustering, the cancer of origin in cases where multiple types of cancer are present in a patient with metastasized cancer. Such information would reveal the clonal origin of a cancer and the most aggressive tumour type amongst a mix of tumour types. Knowledge such as these could potentially revolutionize cancer treatment in identifying the most aggressive cancer to tackle where significant clinical benefit could be obtained. Thus, blood biopsy holds important utility as a tool for informing the cancer types present through DNA sequencing of isolated circulating tumour cells. Such information could emanate from single cell sequencing or pooled processing of a population of cells. Specifically, pooled population informs the aggregate mutational signature useful for chemotherapeutic drug selection, while single cell sequencing identifies particular mutational profile in each cancer type in a patient with metastasized cancer. But, a future beholds where single cell RNA-sequencing is applied to circulating tumour cells at the clinical level, which could potentially yield differential gene expression information that could identify active molecular targets in need of inactivation by chemotherapeutic drugs such as inhibitors." @default.
- W4250734902 created "2022-05-12" @default.
- W4250734902 creator A5004074519 @default.
- W4250734902 date "2019-04-04" @default.
- W4250734902 modified "2023-10-16" @default.
- W4250734902 title "Blood biopsy profiles circulating tumour cells which hold clues to cancer treatment" @default.
- W4250734902 doi "https://doi.org/10.7287/peerj.preprints.27635" @default.
- W4250734902 hasPublicationYear "2019" @default.
- W4250734902 type Work @default.
- W4250734902 citedByCount "0" @default.
- W4250734902 crossrefType "posted-content" @default.
- W4250734902 hasAuthorship W4250734902A5004074519 @default.
- W4250734902 hasBestOaLocation W42507349021 @default.
- W4250734902 hasConcept C121608353 @default.
- W4250734902 hasConcept C142724271 @default.
- W4250734902 hasConcept C203014093 @default.
- W4250734902 hasConcept C2777306565 @default.
- W4250734902 hasConcept C2779013556 @default.
- W4250734902 hasConcept C2779134260 @default.
- W4250734902 hasConcept C2779529041 @default.
- W4250734902 hasConcept C2908647359 @default.
- W4250734902 hasConcept C502942594 @default.
- W4250734902 hasConcept C54355233 @default.
- W4250734902 hasConcept C61238886 @default.
- W4250734902 hasConcept C71924100 @default.
- W4250734902 hasConcept C86803240 @default.
- W4250734902 hasConcept C96232424 @default.
- W4250734902 hasConcept C99454951 @default.
- W4250734902 hasConceptScore W4250734902C121608353 @default.
- W4250734902 hasConceptScore W4250734902C142724271 @default.
- W4250734902 hasConceptScore W4250734902C203014093 @default.
- W4250734902 hasConceptScore W4250734902C2777306565 @default.
- W4250734902 hasConceptScore W4250734902C2779013556 @default.
- W4250734902 hasConceptScore W4250734902C2779134260 @default.
- W4250734902 hasConceptScore W4250734902C2779529041 @default.
- W4250734902 hasConceptScore W4250734902C2908647359 @default.
- W4250734902 hasConceptScore W4250734902C502942594 @default.
- W4250734902 hasConceptScore W4250734902C54355233 @default.
- W4250734902 hasConceptScore W4250734902C61238886 @default.
- W4250734902 hasConceptScore W4250734902C71924100 @default.
- W4250734902 hasConceptScore W4250734902C86803240 @default.
- W4250734902 hasConceptScore W4250734902C96232424 @default.
- W4250734902 hasConceptScore W4250734902C99454951 @default.
- W4250734902 hasLocation W42507349021 @default.
- W4250734902 hasOpenAccess W4250734902 @default.
- W4250734902 hasPrimaryLocation W42507349021 @default.
- W4250734902 hasRelatedWork W10013529 @default.
- W4250734902 hasRelatedWork W10046284 @default.
- W4250734902 hasRelatedWork W10477029 @default.
- W4250734902 hasRelatedWork W10520748 @default.
- W4250734902 hasRelatedWork W14687542 @default.
- W4250734902 hasRelatedWork W2090429 @default.
- W4250734902 hasRelatedWork W4947256 @default.
- W4250734902 hasRelatedWork W684291 @default.
- W4250734902 hasRelatedWork W7207526 @default.
- W4250734902 hasRelatedWork W9265739 @default.
- W4250734902 isParatext "false" @default.
- W4250734902 isRetracted "false" @default.
- W4250734902 workType "article" @default.