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• W4250778233 abstract "<b>Background:</b> In a previous study [1], FRI was used to predict regional lung deposition from a pMDI+VHC and a commonly prescribed mid-resistance DPI to a representative asthmatic adult respiratory tract. <b>Objective:</b> To compare the relative cost of using a DPI and a pMDI+VHC to deliver fluticasone/salmeterol (FP/SX; Seretide®) in patients for whom medium-dose ICS maintenance therapy is appropriate. <b>Methods:</b> Comparisons were based on FP/SX 125/25µg 2 puffs twice daily for the pMDI option, with yearly cost inputs of £281.4+5.2 for the pMDI + VHC obtained from a relevant source in the United Kingdom (www.rightbreathe.com). The DPI option was based on FP/SX 250/50µg 1 inhalation twice daily, with yearly cost inputs of £420. Drug delivery data was taken from the aforementioned study [1], looking at percentage of label dose delivered to the lungs for pMDI/VHC and DPI systems, using an optimal inhalation technique. <b>Results:</b> The mass (µg) of FP and SX delivered per £ are reported in the table. <b>Conclusion:</b> The pMDI/VHC system, using this assessment, was nearly five times as cost effective as the DPI system. Further analysis is required to determine if there would be any quality-adjusted life-year (QALY) effects based on the chosen intervention. [1] Suggett et al. A Comparison, Using Functional Respiratory Imaging (FRI), of Adult Airway Deposition Profiles from a Pressurized Metered Dose Inhaler with Valved Holding Chamber (pMDI/VHC) and Two Dry Powder Inhalers (DPI). Proceedings of RDD Europe 2021" @default.
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• W4250778233 date "1991-09-01" @default.
• W4250778233 modified "2023-10-14" @default.
• W4250778233 title "Birthweight ratio." @default.
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• W4250778233 doi "https://doi.org/10.1136/adc.66.9.1099-b" @default.
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