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- W4250893837 abstract "Abstract The short-chain fatty acid n-butyrate has recently been shown in vitro to specifically downregulate Tcell reactivity to nominal antigen or to alloantigen, which possibly results from inhibition of cell cycle progression in early G1 phase during antigen contact. In the present study, we investigated the effect of cyclosporin A (CyA) on the modulation of alloreactivity in human mixed lymphocyte culture (MLC) by n-butyrate. Whereas in primary culture, CyA additively enhanced inhibition of DNA synthesis by n-butyrate, the effect of this agent on secondary Tcell reactivity was clearly antagonized by CyA. Thus, specific downregulation of prolifer-ative responsiveness to restimula-tion with antigen from the original donor, observed in cultures pre-treated with n-butyrate alone, was at least partially prevented by the addition of CyA to the primary culture. Our in vitro finding indicates that specific downregulation of Tcell alloreactivity by n-butyrate might depend on a calcium-dependent Tcell receptor (TCR)-medi-ated signal sensitive to the immuno-suppressive action of CyA." @default.
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- W4250893837 date "1996-08-01" @default.
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- W4250893837 title "Induction of alloantigen-specific hyporesponsiveness in vitro by n-butyrate: antagonistic effect of cyclosporin A" @default.
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- W4250893837 doi "https://doi.org/10.1111/j.1432-2277.1996.tb01640.x" @default.
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