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- W4250973405 endingPage "117739280700200" @default.
- W4250973405 startingPage "117739280700200" @default.
- W4250973405 abstract "Trypanosomiasis and leishmaniasis are two debilitating disease groups caused by parasites of Trypanosoma and Leishmania spp. and affecting millions of people worldwide. A brief outline of the potential targets for rational drug design against these diseases are presented, with an emphasis placed on the enzyme trypanothione reductase. Trypanothione reductase was identified as unique to parasites and proposed to be an effective target against trypanosomiasis and leishmaniasis. The biochemical basis of selecting this enzyme as a target, with reference to the simile and contrast to human analogous enzyme glutathione reductase, and the structural aspects of its active site are presented. The process of designing selective inhibitors for the enzyme trypanothione reductase has been discussed. An overview of the different chemical classes of inhibitors of trypanothione reductase with their inhibitory activities against the parasites and their prospects as future chemotherapeutic agents are briefly revealed." @default.
- W4250973405 created "2022-05-12" @default.
- W4250973405 creator A5076541930 @default.
- W4250973405 date "2007-01-01" @default.
- W4250973405 modified "2023-10-06" @default.
- W4250973405 title "Trypanothione Reductase: A Viable Chemotherapeutic Target for Antitrypanosomal and Antileishmanial Drug Design" @default.
- W4250973405 cites W10267725 @default.
- W4250973405 cites W1574734617 @default.
- W4250973405 cites W1585308289 @default.
- W4250973405 cites W1592195230 @default.
- W4250973405 cites W1604646983 @default.
- W4250973405 cites W1743444384 @default.
- W4250973405 cites W1817105817 @default.
- W4250973405 cites W1823258013 @default.
- W4250973405 cites W1965388874 @default.
- W4250973405 cites W1966263769 @default.
- W4250973405 cites W1967866945 @default.
- W4250973405 cites W1973887930 @default.
- W4250973405 cites W1976830858 @default.
- W4250973405 cites W1980257407 @default.
- W4250973405 cites W1986962250 @default.
- W4250973405 cites W1989369846 @default.
- W4250973405 cites W1991428543 @default.
- W4250973405 cites W1996393950 @default.
- W4250973405 cites W1997310440 @default.
- W4250973405 cites W2001311382 @default.
- W4250973405 cites W2001957365 @default.
- W4250973405 cites W2002980997 @default.
- W4250973405 cites W2006184077 @default.
- W4250973405 cites W2006723796 @default.
- W4250973405 cites W2009649118 @default.
- W4250973405 cites W2009746444 @default.
- W4250973405 cites W2010015373 @default.
- W4250973405 cites W2011344657 @default.
- W4250973405 cites W2016535624 @default.
- W4250973405 cites W2017140568 @default.
- W4250973405 cites W2019446177 @default.
- W4250973405 cites W2023356380 @default.
- W4250973405 cites W2025955083 @default.
- W4250973405 cites W2025978382 @default.
- W4250973405 cites W2027003225 @default.
- W4250973405 cites W2027602317 @default.
- W4250973405 cites W2030180741 @default.
- W4250973405 cites W2033695597 @default.
- W4250973405 cites W2035824043 @default.
- W4250973405 cites W2035855774 @default.
- W4250973405 cites W2036330755 @default.
- W4250973405 cites W2039888692 @default.
- W4250973405 cites W2040369578 @default.
- W4250973405 cites W2042571733 @default.
- W4250973405 cites W2045265357 @default.
- W4250973405 cites W2045915921 @default.
- W4250973405 cites W2046213732 @default.
- W4250973405 cites W2047838065 @default.
- W4250973405 cites W2049013030 @default.
- W4250973405 cites W2051752014 @default.
- W4250973405 cites W2052075760 @default.
- W4250973405 cites W2052564966 @default.
- W4250973405 cites W2054591552 @default.
- W4250973405 cites W2055194259 @default.
- W4250973405 cites W2055205561 @default.
- W4250973405 cites W2057080473 @default.
- W4250973405 cites W2059027852 @default.
- W4250973405 cites W2059953844 @default.
- W4250973405 cites W2059975739 @default.
- W4250973405 cites W2065081489 @default.
- W4250973405 cites W2070034593 @default.
- W4250973405 cites W2070211116 @default.
- W4250973405 cites W2072079428 @default.
- W4250973405 cites W2072097917 @default.
- W4250973405 cites W2075055658 @default.
- W4250973405 cites W2075178763 @default.
- W4250973405 cites W2075224137 @default.
- W4250973405 cites W2078783287 @default.
- W4250973405 cites W2080888478 @default.
- W4250973405 cites W2083678132 @default.
- W4250973405 cites W2087158727 @default.
- W4250973405 cites W2096197202 @default.
- W4250973405 cites W2103181632 @default.
- W4250973405 cites W2106837596 @default.
- W4250973405 cites W2109643580 @default.
- W4250973405 cites W2116251790 @default.
- W4250973405 cites W2130432349 @default.
- W4250973405 cites W2141244896 @default.
- W4250973405 cites W2142468661 @default.
- W4250973405 cites W2148686101 @default.
- W4250973405 cites W2161026946 @default.
- W4250973405 cites W2164679842 @default.
- W4250973405 cites W2167047804 @default.
- W4250973405 cites W2179459165 @default.
- W4250973405 cites W2202496068 @default.
- W4250973405 cites W2213481583 @default.
- W4250973405 cites W2279417831 @default.
- W4250973405 cites W2321540468 @default.
- W4250973405 cites W2487661078 @default.
- W4250973405 cites W2953374754 @default.
- W4250973405 cites W4253223811 @default.
- W4250973405 cites W97051736 @default.