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- W4250974311 abstract "Abstract Purpose : To evaluate the correlation between silodosin and Intraoperative Floppy Iris Syndrome (IFIS) and compare it with other a1- adrenergic receptor antagonists (a1-ARAs) and other factors predisposing to IFIS. Methods : From the cases who underwent phacoemulsification between 2014 and 2020, we identified all patients who, during their preoperative assessment, reported an a1-ARAs intake (exposed group). These patients were matched utilizing a propensity score matching analysis, with an otherwise homogenous group of patients (control group), based on demographics and systemic/ocular comorbidities. Results : 350 patients were included in each group. In the exposed group, 177 (50.6%) patients were exposed to tamsulosin, 105 (30%) to alfuzosin, 43 (12.2%) to silodosin. Regarding IFIS, it was observed in 21.5% of patients on tamsulosin (38/177), 11.4% on alfuzosin (12/105), 37.2% on silodosin (16/43), and 3.4% in the controlled group (12/350). In a multiple regression model analysis, the only two factors that were significantly associated with IFIS development were silodosin and tamsulosin yielding an adjusted odds ratio of 8.471 (95%CI: 4.005-17.920), and 3.803 (95%CI: 2.231-6.485), respectively. Conclusion : Silodosin has been demonstrated as a predisposing factor, strongly correlated with IFIS development. These results should increase awareness to cataract surgeons, to carefully assess their patients preoperatively for exposure to silodosin, and employ the appropriate prophylactic measures to ameliorate the impact of silodosin intake on the surgical outcome." @default.
- W4250974311 created "2022-05-12" @default.
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- W4250974311 date "2021-04-30" @default.
- W4250974311 modified "2023-09-26" @default.
- W4250974311 title "Silodosin as a predisposing factor of Intraoperative Floppy Iris Syndrome (IFIS): an observational propensity score-matching cohort study" @default.
- W4250974311 doi "https://doi.org/10.21203/rs.3.rs-439878/v1" @default.
- W4250974311 hasPublicationYear "2021" @default.
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