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- W4251010642 abstract "DURING the past quarter-century, studies of the insulin molecule have elucidated details of its biosynthesis, structure, and function. These studies of insulin, a two-chain peptide hormone with a molecular weight of 6000, have provided a framework for the understanding of the clinical correlates of abnormalities of the insulin molecule and its precursors, and a model for the study of other peptide hormones and proteins.Insulin is synthesized as a larger single-chain precursor, pre-proinsulin, which is processed to proinsulin and then to the biologically active molecule, insulin.1 Figure 1 shows the proinsulin molecule, consisting of the A and B chains of insulin, connected . . ." @default.
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- W4251010642 date "1980-01-17" @default.
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- W4251010642 title "The Insulinopathies" @default.
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- W4251010642 doi "https://doi.org/10.1056/nejm198001173020308" @default.
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