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- W4251091689 abstract "Incretin-based medications make use of the glucose-lowering properties of the gut-derived incretin hormone glucagon-like peptide 1 (GLP-1), which glucose-dependently stimulates insulin secretion, suppresses glucagon secretion, decelerates gastric emptying, and reduces appetite and food intake. GLP-1 itself has a very short half-life. Therefore, longer acting GLP-1 receptor agonists like exenatide, liraglutide, exenatide once weekly, and lixisenatide need to be injected subcutaneously at intervals between twice daily and once weekly, or the activity of the proteolytic enzyme dipeptidyl peptidase-4 (DPP-4) needs to be inhibited by DPP-4 inhibitors such as sitagliptin, vildagliptin, saxagliptin, linagliptin, and alogliptin in order to exploit this potential. Incretin-based medications do not provoke hypoglycemia, and either induce some weight loss (incretin mimetics) or are weight-neutral (DPP-4 inhibitors). Incretin mimetics and DPP-4 inhibitors are mainly used as an add-on to oral antidiabetic agents, but can also be used in conjunction with insulin treatment." @default.
- W4251091689 created "2022-05-12" @default.
- W4251091689 creator A5002832666 @default.
- W4251091689 creator A5067359287 @default.
- W4251091689 date "2015-03-06" @default.
- W4251091689 modified "2023-10-16" @default.
- W4251091689 title "Incretin-based therapies" @default.
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- W4251091689 doi "https://doi.org/10.1002/9781118387658.ch48" @default.
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