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- W4251100277 abstract "A reduction in the expected number of coronary events among patients at high risk for heart disease is ascribed to the drug probucol, according to a Finnish study presented at a recent international conference on lipoproteins and coronary atherosclerosis in Lugano, Switzerland. Since the agent also lowered the patients' high-density lipoprotein (HDL)-cholesterol levels, the findings question the growing belief that high levels of HDL may protect against heart disease. In the five-year study, the incidence of sudden death and fatal and nonfatal myocardial infarction among 184 persons who took probucol in conjunction with a low-cholesterol diet was calculated as 9 per 1,000 per five years, said Dr Tatu Miettinen of the Second Department of Medicine, University of Helsinki. According to a risk index calculated on the basis of initial cholesterol levels, age, weight, blood pressure, and other factors, the expected coronary incidence in this group would have been 18±15 per" @default.
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- W4251100277 date "1981-11-20" @default.
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- W4251100277 title "Is it harmful to lower HDL levels?" @default.
- W4251100277 doi "https://doi.org/10.1001/jama.246.20.2311" @default.
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