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• W4251110502 abstract "Research Article1 December 1991free access Trypanosoma brucei glycosomal glyceraldehyde-3-phosphate dehydrogenase genes are stage-regulated at the transcriptional level. N. Bakalara N. Bakalara International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases ICP/TROP 74.9, Brussels, Belgium. Search for more papers by this author G. Kendall G. Kendall International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases ICP/TROP 74.9, Brussels, Belgium. Search for more papers by this author P.A. Michels P.A. Michels International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases ICP/TROP 74.9, Brussels, Belgium. Search for more papers by this author F.R. Opperdoes F.R. Opperdoes International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases ICP/TROP 74.9, Brussels, Belgium. Search for more papers by this author N. Bakalara N. Bakalara International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases ICP/TROP 74.9, Brussels, Belgium. Search for more papers by this author G. Kendall G. Kendall International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases ICP/TROP 74.9, Brussels, Belgium. Search for more papers by this author P.A. Michels P.A. Michels International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases ICP/TROP 74.9, Brussels, Belgium. Search for more papers by this author F.R. Opperdoes F.R. Opperdoes International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases ICP/TROP 74.9, Brussels, Belgium. Search for more papers by this author Author Information N. Bakalara1, G. Kendall1, P.A. Michels1 and F.R. Opperdoes1 1International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases ICP/TROP 74.9, Brussels, Belgium. The EMBO Journal (1991)10:3861-3868https://doi.org/10.1002/j.1460-2075.1991.tb04955.x Retraction(s) for this article Trypanosoma brucei glycosomal glyceraldehyde-3-phosphate dehydrogenase genes are stage-regulated at the transcription level.01 October 1992 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Regions 5′ of the glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) gene from Trypanosoma brucei were tested for their ability to promote chloramphenicol acetyl-transferase (CAT) expression on reintroduction by electroporation into the parasite. Deletion analysis mapped the gGAPDH promoter to within 403 nts of the start of translation. A transcription initiation site was mapped at around −190 nts from the ATG start codon by RNase protection and by primer extension. The higher expression of gGAPDH in bloodstream T. brucei, compared to procyclic (insect) forms, was largely attributed to differences in promoter activity. The gGAPDH promoter gave rise to relatively high CAT signals upon transfection into bloodstream T. brucei and relatively low signals in procyclic T. brucei, compared with levels resulting from transfection with the procyclic acidic repetitive protein (PARP) promoter. In addition, RNase protection data showed a higher level of gGAPDH primary transcripts in bloodstream. T. brucei. The PARP mini-exon addition region abolished transient CAT expression directed by either the gGAPDH or PARP promoters in bloodstream T. brucei implying that transplicing can be a point of stage-specific gene regulation. Previous ArticleNext Article Volume 10Issue 121 December 1991In this issue RelatedDetailsLoading ..." @default.
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• W4251110502 title "Trypanosoma brucei glycosomal glyceraldehyde-3-phosphate dehydrogenase genes are stage-regulated at the transcriptional level." @default.
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