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- W4251134056 abstract "Retrieving a memory initiates a window of vulnerability for that memory. Simple behavioural methods can modify distressing memories during this window, eliminating fear reactions to traumatic reminders. Reconsolidation is a natural mechanism in human memory: the reconsolidation phase allows new information available at the time of retrieval to be incorporated into an old memory. Although pharmacological blockade of reconsolidation has been used to prevent the return of fear in animal models, many of these manipulations involve compounds that are toxic to humans. Elizabeth Phelps and co-workers now report a non-invasive technique of rewriting fear memories that avoids the use of drugs. The procedure is based on an established technique in which memories of traumatic events are 'extinguished' by repeated exposure to traumatic reminders in a safe environment. This works up to a point, but memories are masked rather than eliminated and can return, for example with the passage of time or due to stress. The new advance lies in timing: if the 'safe' information is introduced during the reconsolidation window of old fear memories, the fear does not return. This work suggests that post-traumatic stress disorder and other anxiety conditions might be responsive to new types of non-invasive therapy." @default.
- W4251134056 created "2022-05-12" @default.
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- W4251134056 date "2010-01-01" @default.
- W4251134056 modified "2023-09-30" @default.
- W4251134056 title "Editing out fear" @default.
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- W4251134056 doi "https://doi.org/10.1038/nature08767" @default.
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