Matches in SemOpenAlex for { <https://semopenalex.org/work/W4251142325> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4251142325 endingPage "424" @default.
- W4251142325 startingPage "415" @default.
- W4251142325 abstract "Rheumatoid arthritis (RA) is a representative autoimmune disease characterized by chronic and destructive inflammatory synovitis. The multiple cytokines play pivotal roles in RA pathogenesis by inducing intracellular signaling, and members of the Janus kinase (JAK) family are essential for such signal transduction. An orally available JAK3 inhibitor, tofacitinib, has been applied for RA, with satisfactory effects and acceptable safety in multiple clinical examinations. From phase 2 dose-finding studies, tofacitinib 5 mg and 10 mg twice a day appear suitable for further evaluation. Subsequently, multiple phase 3 studies were carried out, and tofacitinib with or without methotrexate (MTX) is efficacious and has a manageable safety profile in active RA patients who are MTX naïve or show inadequate response to methotrexate (MTX-IR), disease-modifying antirheumatic drugs (DMARD)-IR, or tumor necrosis factor (TNF)-inhibitor-IR. The common adverse events were infections, such as nasopharyngitis; increases in cholesterol, transaminase, and creatinine; and decreases in neutrophil counts. Although the mode of action of tofacitinib remains unclear, we clarified that the inhibitory effects of tofacitinib could be mediated through suppression of interleukin (IL)-17 and interferon (IFN)-γ production and proliferation of CD4+ T cells in the inflamed synovium. Taken together, an orally available kinase inhibitor tofacitinib targeting JAK-mediated signals would be expected to be a new option for RA treatment." @default.
- W4251142325 created "2022-05-12" @default.
- W4251142325 creator A5015953107 @default.
- W4251142325 creator A5034591782 @default.
- W4251142325 date "2013-05-01" @default.
- W4251142325 modified "2023-10-18" @default.
- W4251142325 title "JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinical" @default.
- W4251142325 cites W1483308173 @default.
- W4251142325 cites W1990105300 @default.
- W4251142325 cites W1994584656 @default.
- W4251142325 cites W1995629248 @default.
- W4251142325 cites W2004627079 @default.
- W4251142325 cites W2016086822 @default.
- W4251142325 cites W2028012252 @default.
- W4251142325 cites W2038705787 @default.
- W4251142325 cites W2038992287 @default.
- W4251142325 cites W2039705502 @default.
- W4251142325 cites W2061785558 @default.
- W4251142325 cites W2073058639 @default.
- W4251142325 cites W2082914369 @default.
- W4251142325 cites W2093804554 @default.
- W4251142325 cites W2095522674 @default.
- W4251142325 cites W2100772783 @default.
- W4251142325 cites W2101217991 @default.
- W4251142325 cites W2106256090 @default.
- W4251142325 cites W2106279826 @default.
- W4251142325 cites W2107003864 @default.
- W4251142325 cites W2117926449 @default.
- W4251142325 cites W2121219094 @default.
- W4251142325 cites W2129948300 @default.
- W4251142325 cites W2133038175 @default.
- W4251142325 cites W2149189075 @default.
- W4251142325 cites W2152877278 @default.
- W4251142325 cites W2155109530 @default.
- W4251142325 cites W2161826678 @default.
- W4251142325 cites W4253469911 @default.
- W4251142325 doi "https://doi.org/10.3109/s10165-012-0799-2" @default.
- W4251142325 hasPublicationYear "2013" @default.
- W4251142325 type Work @default.
- W4251142325 citedByCount "47" @default.
- W4251142325 countsByYear W42511423252013 @default.
- W4251142325 countsByYear W42511423252014 @default.
- W4251142325 countsByYear W42511423252015 @default.
- W4251142325 countsByYear W42511423252016 @default.
- W4251142325 countsByYear W42511423252017 @default.
- W4251142325 countsByYear W42511423252018 @default.
- W4251142325 countsByYear W42511423252019 @default.
- W4251142325 countsByYear W42511423252020 @default.
- W4251142325 countsByYear W42511423252021 @default.
- W4251142325 countsByYear W42511423252022 @default.
- W4251142325 countsByYear W42511423252023 @default.
- W4251142325 crossrefType "journal-article" @default.
- W4251142325 hasAuthorship W4251142325A5015953107 @default.
- W4251142325 hasAuthorship W4251142325A5034591782 @default.
- W4251142325 hasBestOaLocation W42511423251 @default.
- W4251142325 hasConcept C112392421 @default.
- W4251142325 hasConcept C126322002 @default.
- W4251142325 hasConcept C197934379 @default.
- W4251142325 hasConcept C203014093 @default.
- W4251142325 hasConcept C2776233030 @default.
- W4251142325 hasConcept C2777077863 @default.
- W4251142325 hasConcept C2777575956 @default.
- W4251142325 hasConcept C2778690821 @default.
- W4251142325 hasConcept C2778886723 @default.
- W4251142325 hasConcept C2781059491 @default.
- W4251142325 hasConcept C71924100 @default.
- W4251142325 hasConcept C98274493 @default.
- W4251142325 hasConceptScore W4251142325C112392421 @default.
- W4251142325 hasConceptScore W4251142325C126322002 @default.
- W4251142325 hasConceptScore W4251142325C197934379 @default.
- W4251142325 hasConceptScore W4251142325C203014093 @default.
- W4251142325 hasConceptScore W4251142325C2776233030 @default.
- W4251142325 hasConceptScore W4251142325C2777077863 @default.
- W4251142325 hasConceptScore W4251142325C2777575956 @default.
- W4251142325 hasConceptScore W4251142325C2778690821 @default.
- W4251142325 hasConceptScore W4251142325C2778886723 @default.
- W4251142325 hasConceptScore W4251142325C2781059491 @default.
- W4251142325 hasConceptScore W4251142325C71924100 @default.
- W4251142325 hasConceptScore W4251142325C98274493 @default.
- W4251142325 hasIssue "3" @default.
- W4251142325 hasLocation W42511423251 @default.
- W4251142325 hasOpenAccess W4251142325 @default.
- W4251142325 hasPrimaryLocation W42511423251 @default.
- W4251142325 hasRelatedWork W142197995 @default.
- W4251142325 hasRelatedWork W1948265060 @default.
- W4251142325 hasRelatedWork W2014330392 @default.
- W4251142325 hasRelatedWork W2132809463 @default.
- W4251142325 hasRelatedWork W2333162414 @default.
- W4251142325 hasRelatedWork W2340001399 @default.
- W4251142325 hasRelatedWork W2755978387 @default.
- W4251142325 hasRelatedWork W2916556513 @default.
- W4251142325 hasRelatedWork W3085086630 @default.
- W4251142325 hasRelatedWork W3160845652 @default.
- W4251142325 hasVolume "23" @default.
- W4251142325 isParatext "false" @default.
- W4251142325 isRetracted "false" @default.
- W4251142325 workType "article" @default.