Matches in SemOpenAlex for { <https://semopenalex.org/work/W4251200606> ?p ?o ?g. }
- W4251200606 endingPage "3771" @default.
- W4251200606 startingPage "3756" @default.
- W4251200606 abstract "The influence of ligand:receptor affinity on B-cell antigen receptor (BCR)-induced apoptosis in the IgM+ Burkitt lymphoma line, Ramos, was evaluated with a group of affinity-diverse murine monoclonal antibodies (MoAbs) specific for human B-cell IgM. The studies showed not only a minimal affinity threshold for the induction of apoptosis, but, interestingly, also a maximal affinity threshold above which increases in affinity were associated with diminished apoptosis. The lesser capacity of high-affinity MoAb to induce apoptosis was paralleled by a lesser capacity to induce receptor cross-linking. At high ligand concentration, high MoAb affinity was also associated with a diminished capacity to induce early protein tyrosine phosphorylation. The compromised capacity of two high-affinity MoAbs to trigger apoptosis may be, at least in part, explained by two separate phenomena that can impair the formation of mIgM cross-links: (1) more stable univalent binding and (2) a tendency for monogamous binding of both MoAb Fab to two Fab epitopes on mIgM. These in vitro studies suggest that the use of the highest affinity MoAbs for antireceptor immunotherapies that depend on receptor cross-linking might, on occasion, be contraindicated." @default.
- W4251200606 created "2022-05-12" @default.
- W4251200606 creator A5010476083 @default.
- W4251200606 creator A5012395661 @default.
- W4251200606 creator A5013911638 @default.
- W4251200606 creator A5051979163 @default.
- W4251200606 creator A5083185135 @default.
- W4251200606 date "1998-11-15" @default.
- W4251200606 modified "2023-09-28" @default.
- W4251200606 title "Evidence for an Upper Affinity Threshold for Anti-IgM–Induced Apoptosis in a Human B-Cell Lymphoma" @default.
- W4251200606 cites W125106425 @default.
- W4251200606 cites W1499065508 @default.
- W4251200606 cites W1500728198 @default.
- W4251200606 cites W1503698979 @default.
- W4251200606 cites W1509808396 @default.
- W4251200606 cites W1510637012 @default.
- W4251200606 cites W1514197537 @default.
- W4251200606 cites W1517881791 @default.
- W4251200606 cites W1518407096 @default.
- W4251200606 cites W1530553925 @default.
- W4251200606 cites W1531578463 @default.
- W4251200606 cites W1532200033 @default.
- W4251200606 cites W1545309797 @default.
- W4251200606 cites W1568859377 @default.
- W4251200606 cites W1585443123 @default.
- W4251200606 cites W1597720787 @default.
- W4251200606 cites W1646691312 @default.
- W4251200606 cites W1769080122 @default.
- W4251200606 cites W1840837207 @default.
- W4251200606 cites W1872465186 @default.
- W4251200606 cites W1880443467 @default.
- W4251200606 cites W1916231325 @default.
- W4251200606 cites W1934599846 @default.
- W4251200606 cites W1942264103 @default.
- W4251200606 cites W1957823630 @default.
- W4251200606 cites W1975242912 @default.
- W4251200606 cites W1975985041 @default.
- W4251200606 cites W1978591172 @default.
- W4251200606 cites W1979129905 @default.
- W4251200606 cites W1979435648 @default.
- W4251200606 cites W1985229594 @default.
- W4251200606 cites W1986456363 @default.
- W4251200606 cites W1986884580 @default.
- W4251200606 cites W1987360148 @default.
- W4251200606 cites W1992699522 @default.
- W4251200606 cites W2007103387 @default.
- W4251200606 cites W2007797448 @default.
- W4251200606 cites W2009035191 @default.
- W4251200606 cites W2009375488 @default.
- W4251200606 cites W2018826402 @default.
- W4251200606 cites W2024203551 @default.
- W4251200606 cites W2049209850 @default.
- W4251200606 cites W2054600777 @default.
- W4251200606 cites W2054923140 @default.
- W4251200606 cites W2055861239 @default.
- W4251200606 cites W2057579672 @default.
- W4251200606 cites W2061308559 @default.
- W4251200606 cites W2063756112 @default.
- W4251200606 cites W2068440493 @default.
- W4251200606 cites W2074376964 @default.
- W4251200606 cites W2075453847 @default.
- W4251200606 cites W2076982480 @default.
- W4251200606 cites W2084523995 @default.
- W4251200606 cites W2104996552 @default.
- W4251200606 cites W2107977922 @default.
- W4251200606 cites W2115411473 @default.
- W4251200606 cites W2127005409 @default.
- W4251200606 cites W2128384878 @default.
- W4251200606 cites W2132156332 @default.
- W4251200606 cites W2163295981 @default.
- W4251200606 cites W2169740898 @default.
- W4251200606 cites W2172393633 @default.
- W4251200606 cites W2263954167 @default.
- W4251200606 cites W238919763 @default.
- W4251200606 cites W4251033031 @default.
- W4251200606 doi "https://doi.org/10.1182/blood.v92.10.3756.422k42_3756_3771" @default.
- W4251200606 hasPublicationYear "1998" @default.
- W4251200606 type Work @default.
- W4251200606 citedByCount "3" @default.
- W4251200606 countsByYear W42512006062022 @default.
- W4251200606 crossrefType "journal-article" @default.
- W4251200606 hasAuthorship W4251200606A5010476083 @default.
- W4251200606 hasAuthorship W4251200606A5012395661 @default.
- W4251200606 hasAuthorship W4251200606A5013911638 @default.
- W4251200606 hasAuthorship W4251200606A5051979163 @default.
- W4251200606 hasAuthorship W4251200606A5083185135 @default.
- W4251200606 hasConcept C116569031 @default.
- W4251200606 hasConcept C147483822 @default.
- W4251200606 hasConcept C153911025 @default.
- W4251200606 hasConcept C159654299 @default.
- W4251200606 hasConcept C163864487 @default.
- W4251200606 hasConcept C170493617 @default.
- W4251200606 hasConcept C190283241 @default.
- W4251200606 hasConcept C195616568 @default.
- W4251200606 hasConcept C203014093 @default.
- W4251200606 hasConcept C2777553839 @default.
- W4251200606 hasConcept C2778453870 @default.
- W4251200606 hasConcept C542903549 @default.