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- W4251210482 abstract "In Brief OBJECTIVE To investigate the association of estrogen receptor α and β3-adrenergic receptor polymorphisms with endometrial cancer risk in Kagoshima, Japan. METHODS Ninety-two patients with endometrial cancer and 65 healthy women were enrolled in this study. Blood samples were collected, and deoxyribonucleic acid (DNA) was extracted. Estrogen receptor α and β3-adrenergic receptor gene variants were analyzed by restriction fragment length polymorphisms using the restriction enzymes, Pvu II, Xba I for estrogen receptor α, and Mva I for β3-adrenergic receptor. Multivariable logistic regression analysis was performed, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. RESULTS The Pvu II PP genotype was associated with a decreased risk of endometrial cancer (multivariable OR 0.23; 95% CI 0.07, 0.82) compared with the pp genotype. The Xba I XX genotype was associated with a decreased risk for endometrial cancer (multivariable OR 0.26; 95% CI 0.09, 0.79) compared with the xx genotype. The Mva I variants were not associated with endometrial cancer risk (multivariable OR 0.55; 95% CI 0.20, 1.51). CONCLUSION Estrogen receptor α polymorphisms, but not β3-adrenergic receptor gene, may be associated with a risk of endometrial cancer. The estrogen receptor a variant is associated with a decreased risk of endometrial cancer." @default.
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- W4251210482 date "2003-09-01" @default.
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- W4251210482 title "Association of Estrogen Receptor α and β3-Adrenergic Receptor Polymorphisms With Endometrial Cancer" @default.
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- W4251210482 doi "https://doi.org/10.1097/00006250-200309000-00015" @default.
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