FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4251221521> ?p ?o ?g. }

• W4251221521 endingPage "2403" @default.
• W4251221521 startingPage "2391" @default.
• W4251221521 abstract "The yeast SLK1 (BCK1) gene encodes a mitogen-activated protein kinase (MAPK) activator protein which functions upstream in a protein kinase cascade that converges on the MAPK Slt2p (Mpk1p). Dominant alleles of SLK1 have been shown to bypass the conditional lethality of a protein kinase C mutation, pkc1-delta, suggesting that Pkc1p may regulate Slk1p function. Slk1p has an important role in morphogenesis and growth control, and deletions of the SLK1 gene are lethal in a spa2-delta mutant background. To search for genes that interact with the SLK1-SLT2 pathway, a synthetic lethal suppression screen was carried out. Genes which in multiple copies suppress the synthetic lethality of slk1-1 spa2-delta were identified, and one, the NHP6A gene, has been extensively characterized. The NHP6A gene and the closely related NHP6B gene were shown previously to encode HMG1-like chromatin-associated proteins. We demonstrate here that these genes are functionally redundant and that multiple copies of either NHP6A or NHP6B suppress slk1-delta and slt2-delta. Strains from which both NHP6 genes were deleted (nhp6-delta mutants) share many phenotypes with pkc1-delta, slk1-delta, and slt2-delta mutants. nhp6-delta cells display a temperature-sensitive growth defect that is rescued by the addition of 1 M sorbitol to the medium, and they are sensitive to starvation. nhp6-delta strains also exhibit a variety of morphological and cytoskeletal defects. At the restrictive temperature for growth, nhp6-delta mutant cells contain elongated buds and enlarged necks. Many cells have patches of chitin staining on their cell surfaces, and chitin deposition is enhanced at the necks of budded cells. nhp6-delta cells display a defect in actin polarity and often accumulate large actin chunks. Genetic and phenotypic analysis indicates that NHP6A and NHP6B function downstream of SLT2. Our results indicate that the Slt2p MAPK pathway in Saccharomyces cerevisiae may mediate its function in cell growth and morphogenesis, at least in part, through high-mobility group proteins." @default.
• W4251221521 created "2022-05-12" @default.
• W4251221521 creator A5024120181 @default.
• W4251221521 creator A5060377007 @default.
• W4251221521 creator A5078437484 @default.
• W4251221521 date "1994-04-01" @default.
• W4251221521 modified "2023-10-18" @default.
• W4251221521 title "NHP6A and NHP6B, which encode HMG1-like proteins, are candidates for downstream components of the yeast SLT2 mitogen-activated protein kinase pathway" @default.
• W4251221521 cites W1012963668 @default.
• W4251221521 cites W1025333691 @default.
• W4251221521 cites W1479869774 @default.
• W4251221521 cites W1504158642 @default.
• W4251221521 cites W1527146660 @default.
• W4251221521 cites W1531194664 @default.
• W4251221521 cites W1537782690 @default.
• W4251221521 cites W1559808711 @default.
• W4251221521 cites W1592806571 @default.
• W4251221521 cites W1798150371 @default.
• W4251221521 cites W1821277660 @default.
• W4251221521 cites W1827528520 @default.
• W4251221521 cites W1889502940 @default.
• W4251221521 cites W1977186059 @default.
• W4251221521 cites W1977302628 @default.
• W4251221521 cites W1982084965 @default.
• W4251221521 cites W1985891609 @default.
• W4251221521 cites W1992976456 @default.
• W4251221521 cites W1993657069 @default.
• W4251221521 cites W1996144310 @default.
• W4251221521 cites W1997218197 @default.
• W4251221521 cites W1998871484 @default.
• W4251221521 cites W1999157780 @default.
• W4251221521 cites W2000661538 @default.
• W4251221521 cites W2007497409 @default.
• W4251221521 cites W2009338295 @default.
• W4251221521 cites W2011115596 @default.
• W4251221521 cites W2011590971 @default.
• W4251221521 cites W2012430176 @default.
• W4251221521 cites W2022658303 @default.
• W4251221521 cites W2037221816 @default.
• W4251221521 cites W2041086054 @default.
• W4251221521 cites W2045894626 @default.
• W4251221521 cites W2047049388 @default.
• W4251221521 cites W2050717506 @default.
• W4251221521 cites W2051333710 @default.
• W4251221521 cites W2051538397 @default.
• W4251221521 cites W2057126981 @default.
• W4251221521 cites W2066846887 @default.
• W4251221521 cites W2079588007 @default.
• W4251221521 cites W2082190322 @default.
• W4251221521 cites W2090306001 @default.
• W4251221521 cites W2097186726 @default.
• W4251221521 cites W2099661865 @default.
• W4251221521 cites W2102824246 @default.
• W4251221521 cites W2112587640 @default.
• W4251221521 cites W2115073295 @default.
• W4251221521 cites W2115180671 @default.
• W4251221521 cites W2130099579 @default.
• W4251221521 cites W2133184855 @default.
• W4251221521 cites W2138270253 @default.
• W4251221521 cites W2141834983 @default.
• W4251221521 cites W2144784260 @default.
• W4251221521 cites W2145330243 @default.
• W4251221521 cites W2146388445 @default.
• W4251221521 cites W2162316280 @default.
• W4251221521 cites W2169333620 @default.
• W4251221521 cites W2171885622 @default.
• W4251221521 cites W4247323657 @default.
• W4251221521 cites W4248096216 @default.
• W4251221521 cites W4255361277 @default.
• W4251221521 doi "https://doi.org/10.1128/mcb.14.4.2391-2403.1994" @default.
• W4251221521 hasPublicationYear "1994" @default.
• W4251221521 type Work @default.
• W4251221521 citedByCount "8" @default.
• W4251221521 crossrefType "journal-article" @default.
• W4251221521 hasAuthorship W4251221521A5024120181 @default.
• W4251221521 hasAuthorship W4251221521A5060377007 @default.
• W4251221521 hasAuthorship W4251221521A5078437484 @default.
• W4251221521 hasConcept C104317684 @default.
• W4251221521 hasConcept C143065580 @default.
• W4251221521 hasConcept C153911025 @default.
• W4251221521 hasConcept C184235292 @default.
• W4251221521 hasConcept C2778502085 @default.
• W4251221521 hasConcept C54355233 @default.
• W4251221521 hasConcept C57074206 @default.
• W4251221521 hasConcept C86803240 @default.
• W4251221521 hasConcept C95444343 @default.
• W4251221521 hasConcept C97029542 @default.
• W4251221521 hasConceptScore W4251221521C104317684 @default.
• W4251221521 hasConceptScore W4251221521C143065580 @default.
• W4251221521 hasConceptScore W4251221521C153911025 @default.
• W4251221521 hasConceptScore W4251221521C184235292 @default.
• W4251221521 hasConceptScore W4251221521C2778502085 @default.
• W4251221521 hasConceptScore W4251221521C54355233 @default.
• W4251221521 hasConceptScore W4251221521C57074206 @default.
• W4251221521 hasConceptScore W4251221521C86803240 @default.
• W4251221521 hasConceptScore W4251221521C95444343 @default.
• W4251221521 hasConceptScore W4251221521C97029542 @default.
• W4251221521 hasIssue "4" @default.

• next