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- W4251246157 abstract "Das Konzept der Wirkstoffähnlichkeit fasst die physikochemischen Eigenchaften niedermolekularer Wirkstoffe zu einem Satz von Regeln zusammen. Von makrocyclischen Wirkstoffen ist bekannt, dass sie diese Regeln brechen. Eine strukturbasierte Makrocyclisierungsstrategie wurde angewendet, um HCV-NS5B-Inhibitoren (HCV=Hepatitis-C-Virus) mit verbesserten pharmakokinetischen Eigenschaften zu entwerfen, die ein Beispiel einer rationalen Strategie darstellt, um die Grenzen des standardmäßigen „wirkstoffähnlichen chemischen Raums“ zu überwinden. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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- W4251246157 date "2012-03-30" @default.
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- W4251246157 title "Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties" @default.
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- W4251246157 doi "https://doi.org/10.1002/ange.201200110" @default.
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