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- W4251282162 abstract "Shortly after the sulfonamide compounds came into general use, physicians recognized that the kidney may be damaged in the course of therapy with these drugs. Two types of renal complications were observed: (1) those due to mechanical obstruction of the pelves, the ureters and the renal tubules by crystals of the sulfonamide compounds and (2) those due to toxic lesions of the kidney without obstruction. Combination of the two forms has likewise been described. In addition to tubular necrosis, which is the usual expression of damage by toxic substances, instances were observed in which interstitial tissue reaction with necrosis was also present. Murphy and his associates<sup>1</sup>observed 1 such instance in the series reported by them. They feel that this type of reaction is probably an expression of severe idiosyncrasy on the part of the renal tissue to the drug. This inflammatory response was also seen in tissues outside" @default.
- W4251282162 created "2022-05-12" @default.
- W4251282162 date "1944-09-30" @default.
- W4251282162 modified "2023-10-14" @default.
- W4251282162 title "RENAL DAMAGE FROM SULFONAMIDE COMPOUNDS" @default.
- W4251282162 doi "https://doi.org/10.1001/jama.1944.02850400034012" @default.
- W4251282162 hasPublicationYear "1944" @default.
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