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- W4251323513 abstract "Abstract Understanding physiological and pathological processes in the brain requires tracking the reversible changes in chemical signals with long‐term stability. We developed a new anti‐biofouling microfiber array to real‐time quantify extracellular Ca 2+ concentrations together with neuron activity across many regions in the mammalian brain for 60 days, in which the signal degradation was < ca. 8 %. The microarray with high tempo‐spatial resolution (ca. 10 μm, ca. 1.3 s) was implanted into 7 brain regions of free‐moving mice to monitor reversible changes of extracellular Ca 2+ upon ischemia‐reperfusion processes. The changing sequence and rate of Ca 2+ in 7 brain regions were different during the stroke. ROS scavenger could protect Ca 2+ influx and neuronal activity after stroke, suggesting the significant influence of ROS on Ca 2+ overload and neuron death. We demonstrated this microarray is a versatile tool for investigating brain dynamic during pathological processes and drug treatment." @default.
- W4251323513 created "2022-05-12" @default.
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- W4251323513 date "2021-04-28" @default.
- W4251323513 modified "2023-10-18" @default.
- W4251323513 title "Long‐Term Tracking and Dynamically Quantifying of Reversible Changes of Extracellular Ca <sup>2+</sup> in Multiple Brain Regions of Freely Moving Animals" @default.
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- W4251323513 doi "https://doi.org/10.1002/ange.202102833" @default.
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